Metastasis and Oxidative Stress: Are Antioxidants a Metabolic Driver of Progression?

Maria Peiris-Pagès; Ubaldo E. Martinez-Outschoorn; Federica Sotgia; Michael P. Lisanti

doi:https://doi.org/10.1016/j.cmet.2015.11.008

doi.org/10.1016/j.cmet.2015.11.008

Metastasis and Oxidative Stress: Are Antioxidants a Metabolic Driver of Progression?

Maria Peiris-Pagès

16

,

Ubaldo E. Martinez-Outschoorn

60

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..., Michael P. Lisanti

141

Cell Metabolism29.00

Volume: 22, Issue: 6, Pages: 956 - 958

Published: Dec 1, 2015

Abstract

The role of reactive oxygen species (ROS) and antioxidants in cancer is controversial because of their context-dependent ability to promote or suppress tumorigenesis. Piskounova et al., 2015Piskounova E. Agathocleous M. Murphy M.M. Hu Z. Huddlestun S.E. Zhao Z. Leitch A.M. Johnson T.M. DeBerardinis R.J. Morrison S.J. Nature. 2015; 527: 186-191Crossref PubMed Scopus (737) Google Scholar now show that ROS limit distant metastasis: only cells with...