An International Multicenter Study of Antimicrobial Consumption and Resistance in Staphylococcus aureus Isolates from 15 Hospitals in 14 Countries

Antibiotic consumption during 1996 was measured in 15 large hospitals from 14 countries and 3000 consecutive Staphylococcus aureus samples were collected, allowing calculation of local resistance rates and typing of isolates. Antibiotic consumption data were converted to defined daily doses (DDD), and similar antibiotics were grouped if they belonged to the same therapeutic subgroup. Variations in hospital size were corrected by using DDD per...