Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains
Abstract
Sestrins are stress-inducible metabolic regulators with two seemingly unrelated but physiologically important functions: reduction of reactive oxygen species (ROS) and inhibition of the mechanistic target of rapamycin complex 1 (mTORC1). How Sestrins fulfil this dual role has remained elusive so far. Here we report the crystal structure of human Sestrin2 (hSesn2), and show that hSesn2 is twofold pseudo-symmetric with two globular subdomains,...
Paper Details
Title
Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains
Published Date
Nov 27, 2015
Journal
Volume
6
Issue
1
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