Original paper
Trafficking and Proteolytic Processing of APP
Volume: 2, Issue: 5, Pages: a006270 - a006270
Published: Feb 7, 2012
Abstract
Accumulations of insoluble deposits of amyloid β-peptide are major pathological hallmarks of Alzheimer disease. Amyloid β-peptide is derived by sequential proteolytic processing from a large type I trans-membrane protein, the β-amyloid precursor protein. The proteolytic enzymes involved in its processing are named secretases. β- and γ-secretase liberate by sequential cleavage the neurotoxic amyloid β-peptide, whereas α-secretase prevents its...
Paper Details
Title
Trafficking and Proteolytic Processing of APP
Published Date
Feb 7, 2012
Volume
2
Issue
5
Pages
a006270 - a006270
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Notes
History