Effect of titanocene dichloride coordination on Watson-Crick base pairing

By high-resolution null 1 H NMR and null 31 P NMR, interactions between titanocene dichloride and 5′-AMP, 5′-TMP, 5′-AMP/5′-TMP have been investigated. The results suggest that titanocene dichloride disrupts Watson-Crick base pairing. On the basis of the NMR data, a new mechanism of antitumor activity of titanocene dichloride is...