Review paper
NAD(P)H Oxidase–Dependent Self-Propagation of Hydrogen Peroxide and Vascular Disease
Abstract
Excessive production of reactive oxygen species in the vasculature contributes to cardiovascular pathogenesis. Among biologically relevant and abundant reactive oxygen species, superoxide (O 2 ·− ) and hydrogen peroxide (H 2 O 2 ) appear most important in redox signaling. Whereas O 2 ·− predominantly induces endothelial dysfunction by rapidly inactivating nitric oxide (NO · ), H 2 O 2 influences different aspects of endothelial cell function via...
Paper Details
Title
NAD(P)H Oxidase–Dependent Self-Propagation of Hydrogen Peroxide and Vascular Disease
Published Date
Apr 29, 2005
Journal
Volume
96
Issue
8
Pages
818 - 822
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