NAD(P)H Oxidase–Dependent Self-Propagation of Hydrogen Peroxide and Vascular Disease

Excessive production of reactive oxygen species in the vasculature contributes to cardiovascular pathogenesis. Among biologically relevant and abundant reactive oxygen species, superoxide (O 2 ·− ) and hydrogen peroxide (H 2 O 2 ) appear most important in redox signaling. Whereas O 2 ·− predominantly induces endothelial dysfunction by rapidly inactivating nitric oxide (NO · ), H 2 O 2 influences different aspects of endothelial cell function via...