Review paper

Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives

Cell45.50
Volume: 152, Issue: 5, Pages: 1146 - 1159
Published: Feb 1, 2013
Abstract
Tet proteins oxidize 5-methylcytosine (mC) to generate 5-hydroxymethyl (hmC), 5-formyl (fC), and 5-carboxylcytosine (caC). The exact function of these oxidative cytosine bases remains elusive. We applied quantitative mass-spectrometry-based proteomics to identify readers for mC and hmC in mouse embryonic stem cells (mESC), neuronal progenitor cells (NPC), and adult mouse brain tissue. Readers for these modifications are only partially...
Paper Details
Title
Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives
Published Date
Feb 1, 2013
Journal
Volume
152
Issue
5
Pages
1146 - 1159
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