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Prevalence and predictors of recurrence of major depressive disorder in the adult population.

Published on Dec 11, 2009in Acta Psychiatrica Scandinavica4.694
· DOI :10.1111/j.1600-0447.2009.01519.x
Florian Hardeveld9
Estimated H-index: 9
,
Jan Spijker24
Estimated H-index: 24
+ 2 AuthorsAartjan T. F. Beekman27
Estimated H-index: 27
(VU: VU University Amsterdam)
Abstract
Objective: Knowledge of the risk of recurrence after recovery of a major depressive disorder (MDD) is of clinical and scientific importance. The purpose of this paper was to provide a systematic review of the prevalence and predictors of recurrence of MDD. Method: Studies were searched in Medline en PsychINFO using the search terms 'recur*', 'relaps*', 'depress*', 'predict*' and course. Results: Recurrence of MDD in specialised mental healthcare settings is high (60% after 5 years, 67% after 10 years and 85% after 15 years) and seems lower in the general population (35% after 15 years). Number of previous episodes and subclinical residual symptoms appear to be the most important predictors. Gender, civil status and socioeconomic status seem not related to the recurrence of MDD. Conclusion: Clinical factors seem the most important predictors of recurrence. Data from studies performed in the general population and primary care on the recurrent course of MDD are scarce.
  • References (40)
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References40
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#1Nil Kaymaz (UM: Maastricht University)H-Index: 8
#2Edwin J. C. G. van den Oord (UM: Maastricht University)H-Index: 123
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Background: Antidepressants are effective in the prevention of relapse after remission from an acute depressive episode. It is unclear, however, to what degree duration of the continuation phase, level of abruptness of antidepressant discontinuation, or the number of previous episodes moderate the prophylactic effect of antidepressants. Data Sources: Searches were conducted to identify all published randomized, placebocontrolled, double-blind clinical trials available for review by May 2007 on t...
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#2Huibo Shao (Johns Hopkins University)H-Index: 5
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Context There are no studies of the natural history of major depressive disorder that lack prevalence and clinic biases. Objectives To estimate risk factors for first lifetime onset and parameters of chronicity following the first episode, including duration, recovery, and recurrence, and to search for predictors of each parameter. Design Prospective population-based cohort study with 23 years of follow-up. Setting East Baltimore, Maryland, an urban setting. Participants Probability sample of 34...
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#1Oliver J. Robinson (University of Cambridge)H-Index: 21
#2Barbara J. Sahakian (University of Cambridge)H-Index: 133
Depressive disorders are amongst the leading causes of disability and mortality worldwide and, as such, it is predicted that by 2010 only cardio-ischaemic disorders will provide a greater burden. In addition to the sizable emotional, individual and social burden, depressive disorders cost an estimated US$83.1 billion per year in the United States alone. In spite of effective treatments, a large proportion of sufferers go on to experience recurrences. With successive recurrences, the likelihood o...
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Objective: The prevailing view of outcome of major depressive disorder (MDD), based on mostly inpatient cohorts sampled from tertiary centers, emphasizes chronicity and frequent recurrences. We investigated the long-term outcome of a regionally representative psychiatric MDD cohort comprising mainly outpatients. Method: The Vantaa Depression Study included 163 patients with DSM-IV MDD (71.5% of those eligible) diagnosed using structured and semi structured interviews and followed up at 6 months,...
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Major depressive disorder is often marked by multiple recurrences. Unfortunately, it is difficult to predict specifically which patients will suffer a recurrence. This study examined whether psychosocial impairment is a risk factor for recurrence. A total of 290 subjects with unipolar major depressive disorder according to Research Diagnostic Criteria (RDC) were prospectively followed for up to 15 years as part of the Collaborative Depression Study (CDS), a multicenter longitudinal observational...
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