Match!

Metabolic stress-induced joint inflammation and osteoarthritis.

Published on Nov 1, 2015in Osteoarthritis and Cartilage4.88
· DOI :10.1016/j.joca.2015.05.016
Alice Courties5
Estimated H-index: 5
(French Institute of Health and Medical Research),
Oreste Gualillo47
Estimated H-index: 47
(Usach: University of Santiago, Chile)
+ 1 AuthorsJ. Sellam22
Estimated H-index: 22
(French Institute of Health and Medical Research)
Abstract
Osteoarthritis (OA) is a heterogeneous disorder with several risk factors. Among them, obesity has a major impact on both loading and non-loading joints. Mechanical overload and activity of systemic inflammatory mediators derived from adipose tissue (adipokines, free fatty acids, reactive oxygen species) provide clues to the increased incidence and prevalence of OA in obesity. Recently, research found greater OA prevalence and incidence in obese patients with cardiometabolic disturbances than “healthy” obese patients, which led to the description of a new OA phenotype - metabolic syndrome (MetS)-associated OA. Indeed, individual metabolic factors (diabetes, dyslipidemia, and hypertension) may increase the risk of obesity-induced OA. This review discusses hypotheses based on pathways specific to a metabolic factor in MetS-associated OA, such as the role of advanced glycation end products and glucose toxicity. A better understanding of these phenotypes based on risk factors will be critical for designing trials of this specific subset of OA.
  • References (143)
  • Citations (68)
References143
Newest
#1T.A. Hoeven (Erasmus University Medical Center)H-Index: 4
#2Maarten J.G. Leening (Erasmus University Medical Center)H-Index: 19
Last.Jacqueline C. M. Witteman (Erasmus University Medical Center)H-Index: 135
view all 11 authors...
#1Faezeh Vasheghani (UdeM: Université de Montréal)H-Index: 4
#2Yue Zhang (UHN: University Health Network)H-Index: 5
Last.Bahareh Saffar (UHN: University Health Network)H-Index: 1
view all 18 authors...
#1Siyoung Yang (Gwangju Institute of Science and Technology)H-Index: 4
#2Je-Hwang Ryu (Chonnam National University)H-Index: 13
Last.Jang-Soo Chun (Gwangju Institute of Science and Technology)H-Index: 29
view all 9 authors...
#1R. Liu (LEI: Leiden University)H-Index: 2
#2Wy Kwok (LEI: Leiden University)H-Index: 2
Last.M. Kloppenburg (LEI: Leiden University)H-Index: 50
view all 9 authors...
Cited By68
Newest
#1Yiqun Zhou (ZJU: Zhejiang University)
#2H. Lu (ZJNU: Zhejiang Chinese Medical University)H-Index: 1
Last.Mengjie Wu (ZJU: Zhejiang University)H-Index: 1
view all 0 authors...
#1Jaqueline L. Rios (U of C: University of Calgary)H-Index: 3
#2Marc R. Bomhof (U of L: University of Lethbridge)H-Index: 10
Last.Walter Herzog (U of C: University of Calgary)H-Index: 67
view all 6 authors...
#1Nicola Veronese (National Research Council)H-Index: 29
#2Curtis Cooper (University of Oxford)H-Index: 163
Last.Gabriel Herrero-BeaumontH-Index: 36
view all 18 authors...
#1Feng Pan (UTAS: University of Tasmania)H-Index: 9
#2Jing Tian (UTAS: University of Tasmania)H-Index: 6
Last.Graeme Jones (UTAS: University of Tasmania)H-Index: 1
view all 0 authors...
#1Feng Pan (UTAS: University of Tasmania)H-Index: 9
#2Jing Tian (UTAS: University of Tasmania)H-Index: 6
Last.Graeme Jones (UTAS: University of Tasmania)H-Index: 75
view all 5 authors...
View next paperCharacterization of diabetic osteoarthritic cartilage and role of high glucose environment on chondrocyte activation: toward pathophysiological delineation of diabetes mellitus-related osteoarthritis