Characterization of sphere-forming cells with stem-like properties from the small cell lung cancer cell line H446
Abstract
A relatively novel paradigm in tumor biology hypothesizes that cancer growth is driven by tumor cells with stem-like properties. However, direct proof of a population of stem cells in small cell lung cancer (SCLC) remains elusive. In this study, we enriched for stem-like cells from the SCLC cell line H446 by growing them as spheres in a defined serum-free medium. Sphere-derived cells have increased in vitro clonogenic and in vivo tumorigenic...
Paper Details
Title
Characterization of sphere-forming cells with stem-like properties from the small cell lung cancer cell line H446
Published Date
Oct 1, 2012
Journal
Volume
323
Issue
2
Pages
161 - 170
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