Clinical evaluation of Moro (Citrus sinensis (L.) Osbeck) orange juice supplementation for the weight management

Published on Dec 2, 2015in Natural Product Research 1.93
· DOI :10.1080/14786419.2014.1000897
Venera Cardile32
Estimated H-index: 32
(University of Catania),
Adriana Carol Eleonora Graziano12
Estimated H-index: 12
(University of Catania),
Alessandro Venditti14
Estimated H-index: 14
Abstract
In the last years, several studies have recently evaluated the beneficial effects of red orange juice (Citrus sinensis (L.) Osbeck) and its active components in weight management and obesity. Moro orange is a cultivar of red orange, particularly rich in active compounds such as anthocyanins, hydroxycinnamic acids, flavone glycosides and ascorbic acid, which displays anti-obesity effects in in vitro and in vivo studies. In this clinical study, the effect of a Moro juice extract (Morosil®, 400 mg/die) supplementation was evaluated in overweight healthy human volunteers for 12 weeks. Results showed that Moro juice extract intake was able to induce a significant reduction in body mass index (BMI) after 4 weeks of treatment (p < 0.05). Moreover, in subjects treated with Moro extract, body weight, BMI, waist and hip circumference were significantly different from the placebo group (p < 0.05). In conclusion, it could be suggested that the active compounds contained in Moro juice have a synergistic effect on fat ...
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References13
Published on Mar 1, 2014in Malawi Medical Journal 1.12
D Segula1
Estimated H-index: 1
Obesity, which broadly refers to excess body fat, has become an important public health problem. Its prevalence continues to increase worldwide.1 As the prevalence of obesity increases so does the burden of its associated co-morbidities.2 Non-communicable diseases and their risk factors including obesity are now becoming a significant problem not only in affluent societies but also in developing countries.3–6 Assessing total body fat accurately requires sophisticated technology which is not read...
42 Citations
Published on Jan 1, 2013in Oxidative Medicine and Cellular Longevity 4.94
Giuseppe Grosso34
Estimated H-index: 34
(University of Catania),
Fabio Galvano48
Estimated H-index: 48
(University of Catania)
+ 7 AuthorsAlessandro Scuderi4
Estimated H-index: 4
(University of Catania)
In recent years, there has been increasing public interest in plant antioxidants, thanks to the potential anticarcinogenic and cardioprotective actions mediated by their biochemical properties. The red (or blood) orange (Citrus sinensis (L.) Osbeck) is a pigmented sweet orange variety typical of eastern Sicily (southern Italy), California, and Spain. In this paper, we discuss the main health-related properties of the red orange that include anticancer, anti-inflammatory, and cardiovascular prote...
41 Citations Source Cite
Published on Mar 1, 2010in International Journal of Obesity 5.16
Lucilla Titta3
Estimated H-index: 3
,
M. Trinei2
Estimated H-index: 2
+ 10 AuthorsPier Giuseppe Pelicci99
Estimated H-index: 99
Objective: To analyze the effect of the juice obtained from two varieties of sweet orange (Citrus sinensis L. Osbeck), Moro (a blood orange) and Navelina (a blond orange), on fat accumulation in mice fed a standard or a high-fat diet (HFD). Methods: Obesity was induced in male C57/B16 mice by feeding a HFD. Moro and Navelina juices were provided instead of water. The effect of an anthocyanin-enriched extract from Moro oranges or purified cyanidin-3-glucoside (C3G) was also analyzed. Body weight ...
91 Citations Source Cite
Published on May 1, 2013in Obesity 4.04
Judith S. Stern45
Estimated H-index: 45
(University of California, Davis),
J. Peerson1
Estimated H-index: 1
(University of California, Davis)
+ 2 AuthorsK.P. Rajeswari1
Estimated H-index: 1
Abstract The clinical effects and tolerability of a novel herbal formulation comprising the extracts of Sphaeranthus indicus and Garcinia mangostana were assessed in two similarly designed randomized, double-blind, placebo-controlled, clinical trials in 100 human subjects with a body mass index (BMI) between 30 and 40 kg/m2. Participants were randomized into two groups receiving either 400 mg of herbal blend twice daily or two identical placebo capsules. All subjects received three meals (2000 k...
8 Citations Source Cite
Published on Jan 1, 2013in Journal of Obesity
Joyce K. Keithley11
Estimated H-index: 11
(Rush University Medical Center),
Susan Mikolaitis2
Estimated H-index: 2
(Rush University Medical Center)
+ 4 AuthorsJehan-Marie Adamji1
Estimated H-index: 1
(Rush University Medical Center)
Background. Few safe and effective dietary supplements are available to promote weight loss. We evaluated the safety and efficacy of glucomannan, a water-soluble fiber supplement, for achieving weight loss in overweight and moderately obese individuals consuming self-selected diets. Methods. Participants were randomly assigned to take 1.33 grams of glucomannan or identically looking placebo capsules with 236.6 mL (8 ounces) of water one hour before breakfast, lunch, and dinner for 8 weeks. The p...
21 Citations Source Cite
Takanori Tsuda25
Estimated H-index: 25
(Doshisha University),
Yuki Ueno3
Estimated H-index: 3
(Doshisha University)
+ 5 AuthorsToshihiko Osawa71
Estimated H-index: 71
(Nagoya University)
Adipocyte dysfunction is strongly associated with the development of obesity and insulin resistance. It is accepted that the regulation of adipocytokine secretion or the adipocyte-specific gene expression is one of the most important targets for the prevention of obesity and amelioration of insulin sensitivity. In this study, we demonstrated that anthocyanins (cyanidin or cyanidin 3-glucoside) have the potency of a unique pharmacological function in isolated rat adipocytes. Treated adipocytes wi...
136 Citations Source Cite
Published on Dec 1, 2006in International Journal of Obesity 5.16
Frank L. Greenway50
Estimated H-index: 50
,
Zhijun Liu15
Estimated H-index: 15
+ 5 AuthorsRonald J. Amen3
Estimated H-index: 3
Top of pageAbstract Objective: A human pilot study testing the safety and effectiveness of NT (Number Ten), a dietary herbal supplement made from rhubarb, ginger, astragulus, red sage and turmeric, to reduce food intake and cause weight loss. Research methods and procedures: A total of 24 healthy women, 18–60 years, body mass index 25–35 kg/m2 on no chronic medication were randomized to four groups of six: (1) oral freeze-dried NT 6 gm/day, (2) bed-dried NT 6 gm/day, (3) freeze-dried NT 12 gm/da...
23 Citations Source Cite
Published on Jan 1, 2012in World Journal of Gastroenterology 3.30
Federico Salamone5
Estimated H-index: 5
(University of Catania),
Giovanni Li Volti31
Estimated H-index: 31
(University of Catania)
+ 8 AuthorsMarco Giorgio32
Estimated H-index: 32
AIM: To establish if the juice of Moro, an anthocyanin-rich orange, may improve liver damage in mice with diet-induced obesity. METHODS: Eight-week-old mice were fed a high-fat diet (HFD) and were administrated water or Moro juice for 12 wk. Liver morphology, gene expression of lipid transcription factors, and metabolic enzymes were assessed. RESULTS: Mice fed HFD displayed increased body weight, insulin resistance and dyslipidemia. Moro juice administration limited body weight gain, enhanced in...
38 Citations Source Cite
Published on Feb 1, 2006in International Journal of Epidemiology 8.36
Rebecca K. Simmons30
Estimated H-index: 30
,
Nicholas J. Wareham157
Estimated H-index: 157
The size and rapidity of the recent increase in the prevalence of obesity is paralleled only by the massive media interest in the causes and implications of these changes and the myriad number of proposed solutions. The availability of information on obesity is overwhelming, but there seems to be common consensus on three points; that obesity is an important public health problem, that the problem is getting worse and that the solution is simple: eat less and exercise more. And yet, although the...
7 Citations Source Cite
Published on Jul 1, 2003in Journal of Nutrition 4.40
Takanori Tsuda25
Estimated H-index: 25
(Doshisha University),
Fumihiko Horio27
Estimated H-index: 27
(Nagoya University)
+ 2 AuthorsToshihiko Osawa71
Estimated H-index: 71
(Nagoya University)
Anthocyanins, which are used as a food coloring, are widely distributed in human diets, suggesting that we ingest large amounts of anthocyanins from plant-based foods. Mice were fed control, cyanidin 3-glucoside-rich purple corn color (PCC), high fat (HF) or HF + PCC diet for 12 wk. Dietary PCC significantly suppressed the HF diet-induced increase in body weight gain, and white and brown adipose tissue weights. Feeding the HF diet markedly induced hypertrophy of the adipocytes in the epididymal ...
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  • Citations (4)
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Cited By4
Published on Sep 16, 2016in Natural Product Research 1.93
Costantino Balestra17
Estimated H-index: 17
(École Normale Supérieure),
Francesco Cimino20
Estimated H-index: 20
(University of Messina)
+ 5 AuthorsFabio Virgili27
Estimated H-index: 27
AbstractNutritional antioxidants have been proposed as an expedient strategy to counter the potentially deleterious effects of scuba diving on endothelial function, flow-mediated dilation (FMD) and heart function. Sixteen volunteers performing a single standard dive (20 min at 33 m) according to US Navy diving procedures were randomly assigned to two groups: one was administered with two doses of 200 mg of an anthocyanins (AC)-rich extract from red oranges, 12 and 4 h before diving. Anthocyanins...
2 Citations Source Cite
Published on Feb 22, 2016in Molecules 3.10
Juan Manuel de Jesús Favela-Hernández4
Estimated H-index: 4
,
Omar González-Santiago6
Estimated H-index: 6
(Universidad Autónoma de Nuevo León)
+ 2 AuthorsMaría del Rayo Camacho-Corona7
Estimated H-index: 7
(Universidad Autónoma de Nuevo León)
Presently the search for new drugs from natural resources is of growing interest to the pharmaceutical industry. Natural products have been the source of new drugs since ancient times. Plants are a good source of secondary metabolites which have been found to have beneficial properties. The present study is a review of the chemistry and pharmacology of Citrus sinensis. This review reveals the therapeutic potential of C. sinensis as a source of natural compounds with important activities that are...
9 Citations Source Cite
Published on Jan 2, 2017in Natural Product Research 1.93
Sara Silva11
Estimated H-index: 11
,
Eduardo M. Costa1
Estimated H-index: 1
+ 2 AuthorsManuela Pintado36
Estimated H-index: 36
AbstractBlueberries are widely recognised as one of the richest sources of bioactive compounds, among which are anthocyanins, though the ripeness of berries has been reported as affecting the phytochemical composition of fruits. Therefore, the present work aimed to evaluate the variation of anthocyanins, and other major phenolics, throughout five ripening stages in four blueberry cultivars. The results showed that the antioxidant capacity and anthocyanin content increased during ripening, reachi...
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Published on Jan 1, 2017in Oxidative Medicine and Cellular Longevity 4.94
Elena Azzini2
Estimated H-index: 2
,
Jasminka Giacometti13
Estimated H-index: 13
,
Gian Luigi Russo29
Estimated H-index: 29
The natural phytochemicals present in foods, including anthocyanins, might play a role in attenuating obesity by producing a decrease in weight and adipose tissue. This review focused on current knowledge about anthocyanins’ role in obesity and its related comorbidities reported in animal models and humans. We summarized their target identification and mechanism of action through several pathways and their final effects on health and well-being. Into consideration of ongoing researches, we highl...
10 Citations Source Cite