Hypotonic versus isotonic saline in hospitalised children: a systematic review

Background: The traditional recommendations which suggest that hypotonic intravenous (IV) maintenance fluids are the solutions of choice in paediatric patients have not been rigorously tested in clinical trials, and may not be appropriate for all children. Aims: To systematically review the evidence from studies evaluating the safety of administering hypotonic versus isotonic IV maintenance fluids in hospitalised children....