Original paper
C. elegans whole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency
Abstract
Mutation is associated with developmental and hereditary disorders, aging, and cancer. While we understand some mutational processes operative in human disease, most remain mysterious. We used Caenorhabditis elegans whole-genome sequencing to model mutational signatures, analyzing 183 worm populations across 17 DNA repair-deficient backgrounds propagated for 20 generations or exposed to carcinogens. The baseline mutation rate in C. elegans was...
Paper Details
Title
C. elegans whole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency
Published Date
Jul 16, 2014
Journal
Volume
24
Issue
10
Pages
1624 - 1636
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Notes
History