Original paper

Switchable Lipids: Conformational Change for Fast pH‐Triggered Cytoplasmic Delivery

Volume: 54, Issue: 43, Pages: 12743 - 12747
Published: Jul 17, 2015
Abstract
We report the use of switchable lipids to improve the endosomal escape and cytosolic delivery of cell-impermeable compounds. The system is based on a conformational reorganization of the lipid structure upon acidification, as demonstrated by NMR spectroscopic studies. When incorporated in a liposome formulation, the switchable lipids triggered bilayer destabilization through fusion even in the presence of poly(ethylene glycol). We observed 88 %...
Paper Details
Title
Switchable Lipids: Conformational Change for Fast pH‐Triggered Cytoplasmic Delivery
Published Date
Jul 17, 2015
Volume
54
Issue
43
Pages
12743 - 12747
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