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Jeanne Leblond
Université de Montréal
26Publications
12H-index
378Citations
Publications 26
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#1Lucie ValeroH-Index: 2
#2Khair AlharethH-Index: 3
Last.Karine AndrieuxH-Index: 1
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Nanomedicine as a therapeutic approach for pregnancy-related diseases could offer improved treatments for the mother while avoiding side effects for the fetus. In this study, we evaluated the potential of liposomes as carriers for small interfering RNAs to placental cells. Three neutral formulations carrying rhodamine-labelled siRNAs were evaluated on an in vitro model, i.e., human primary villous cytotrophoblasts. siRNA internalization rate from lipoplexes were compared to the one in the presen...
2 CitationsSource
#1Alexander J. Cunningham (UdeM: Université de Montréal)H-Index: 2
#2Mattieu Robinson (Université de Sherbrooke)H-Index: 1
Last.X. X. Zhu (UdeM: Université de Montréal)H-Index: 36
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Doxorubicin (Dox) is a drug of choice in the design of drug delivery systems directed toward breast cancers, but is often limited by loading and control over its release from polymer micelles. Bile acid-based block copolymers present certain advantages over traditional polymer-based systems for drug delivery purposes, since they can enable a higher drug loading via the formation of a reservoir through their aggregation process. In this study, hydrophobic and electrostatic interactions are compar...
6 CitationsSource
#1Kevin Plourde (UdeM: Université de Montréal)H-Index: 1
#2Rabeb Mouna Derbali (UdeM: Université de Montréal)H-Index: 2
Last.Jeanne Leblond (UdeM: Université de Montréal)H-Index: 12
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Abstract Aptamer technology has shown much promise in cancer therapeutics for its targeting abilities. However, its potential to improve drug loading and release from nanocarriers has not been thoroughly explored. In this study, we employed drug-binding aptamers to actively load drugs into liposomes. We designed a series of DNA aptamer sequences specific to doxorubicin, displaying multiple binding sites and various binding affinities. The binding ability of aptamers was preserved when incorporat...
12 CitationsSource
#1Lucie Giraud (UdeM: Université de Montréal)H-Index: 2
#2Warren Viricel (UdeM: Université de Montréal)H-Index: 2
Last.Suzanne Giasson (UdeM: Université de Montréal)H-Index: 20
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Abstract As double stranded, single stranded siRNA (ss-siRNA) has demonstrated gene silencing activity but still requires efficient carriers to reach its cytoplasmic target. To better understand the fundamental aspect driving the complexation of ss-siRNA with nanocarriers, the interactions between surfaces of various compositions across a ss-siRNA solution were investigated using the Surface Forces Apparatus. The results show that ss-siRNA can adsorb onto hydrophilic (positively and negatively c...
1 CitationsSource
#1Warren Viricel (UdeM: Université de Montréal)H-Index: 2
#2S. Poirier (MHI: Montreal Heart Institute)H-Index: 1
Last.Jeanne Leblond (UdeM: Université de Montréal)H-Index: 12
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A pH-sensitive molecular switch able to change its conformation upon protonation at endosomal pH values is embedded into the structure of cationic lipidoid materials, thus conferring endosomal escape properties. Involvement of the conformational switch in the endosomal escape process was confirmed and leading material identified was able to induce efficient gene knockdown both in vitro and in vivo. The lipid nanoparticles reported here are promising for therapeutic applications and this work cou...
13 CitationsSource
#1Mirza Akram Hossain (UdeM: Université de Montréal)H-Index: 1
#2Augustine Lalloz (UdeM: Université de Montréal)H-Index: 2
Last.Jeanne Leblond (UdeM: Université de Montréal)H-Index: 12
view all 9 authors...
Abstract In this work, we propose pharmaceutical textiles imprinted with lipid microparticles of Econazole nitrate (ECN) as a mean to improve patient compliance while maintaining drug activity. Lipid microparticles were prepared and characterized by laser diffraction (3.5 ± 0.1 μm). Using an optimized screen-printing method, microparticles were deposited on textiles, as observed by scanning electron microscopy. The drug content of textiles (97 ± 3 μg/cm 2 ) was reproducible and stable up to 4 mo...
1 CitationsSource
#1Warren Viricel (UdeM: Université de Montréal)H-Index: 2
#2Amira Mbarek (UdeM: Université de Montréal)H-Index: 2
Last.Jeanne Leblond (UdeM: Université de Montréal)H-Index: 12
view all 3 authors...
We report the use of switchable lipids to improve the endosomal escape and cytosolic delivery of cell-impermeable compounds. The system is based on a conformational reorganization of the lipid structure upon acidification, as demonstrated by NMR spectroscopic studies. When incorporated in a liposome formulation, the switchable lipids triggered bilayer destabilization through fusion even in the presence of poly(ethylene glycol). We observed 88 % release of sulforhodamine B in 15 min at pH 5, and ...
24 CitationsSource
#1Warren Viricel (UdeM: Université de Montréal)H-Index: 2
#2Amira Mbarek (UdeM: Université de Montréal)H-Index: 2
Last.Jeanne Leblond (UdeM: Université de Montréal)H-Index: 12
view all 3 authors...
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