Original paper
CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes
Abstract
Genome editing tools such as the clustered regularly interspaced short palindromic repeat (CRISPR)-associated system (Cas) have been widely used to modify genes in model systems including animal zygotes and human cells, and hold tremendous promise for both basic research and clinical applications. To date, a serious knowledge gap remains in our understanding of DNA repair mechanisms in human early embryos, and in the efficiency and potential...
Paper Details
Title
CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes
Published Date
Apr 18, 2015
Journal
Volume
6
Issue
5
Pages
363 - 372
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Notes
History