Incompatibility study of ibuprofen in ternary interactive mixture by using differential scanning calorimetry

The main objective of this work was to use the differential scanning calorimetry in conjunction with optical microscopy to study the compatibility of ibuprofen with lactose and polyvinylpyrrolidone and to provide an explanation(s) for the reduction in the dissolution rate observed from the ternary interactive mixture containing ibuprofen in previous study. Mixtures containing micronized ibuprofen–fine lactose 90:10 and 20:80 w/w showed a...