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Journal of Thermal Analysis and Calorimetry
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2.47
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20173
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#1Gongnan XieH-Index: 29
#2Sandra K. S. Boetcher (Embry-Riddle Aeronautical University, Daytona Beach)H-Index: 10
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Aripiprazole (ARP) is one of the newest antipsychotic drugs, exhibiting very low aqueous solubility and high lipophilicity. Considering the necessity of improvement of ARP physicochemical properties and its biopharmaceutical profile, cyclodextrin complexation of the drug substance was performed. As selected cyclodextrin, a functionalized β-cyclodextrin was used, namely heptakis(2,6-di-O-methyl)-β-cyclodextrin (DIMEB), and the supramolecular adduct ARP/DIMEB was prepared by kneading technique and...
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Thermal analysis
Organic chemistry
Inorganic chemistry
Chemistry
Differential scanning calorimetry