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The Genome-based Knowledge Management in Cycles model: a complex adaptive systems framework for implementation of genomic applications

Published on Mar 1, 2011in Personalized Medicine1.414
· DOI :10.2217/pme.11.5
Nedal H. Arar18
Estimated H-index: 18
,
Sara J. Knight34
Estimated H-index: 34
+ 1 AuthorsAmalia M Issa12
Estimated H-index: 12
Abstract
The main mission of the Genomic Applications in Practice and Prevention Network™ is to advance collaborative efforts involving partners from across the public health sector to realize the promise of genomics in healthcare and disease prevention. We introduce a new framework that supports the Genomic Applications in Practice and Prevention Network mission and leverages the characteristics of the complex adaptive systems approach. We call this framework the Genome-based Knowledge Management in Cycles model (G-KNOMIC). G-KNOMIC proposes that the collaborative work of multidisciplinary teams utilizing genome-based applications will enhance translating evidence-based genomic findings by creating ongoing knowledge management cycles. Each cycle consists of knowledge synthesis, knowledge evaluation, knowledge implementation and knowledge utilization. Our framework acknowledges that all the elements in the knowledge translation process are interconnected and continuously changing. It also recognizes the importance...
  • References (79)
  • Citations (5)
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References79
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#1Harold E. Varmus (NIH: National Institutes of Health)H-Index: 120
On a June day nearly 10 years ago, the leaders of the United States and the United Kingdom, accompanied by the leaders of the public and private teams deciphering the human genome, announced that a draft sequence had been completed. That occasion was rich with promises of new and more powerful ways to understand, diagnose, prevent, and treat disease. Two years later, the Journal published a series of articles that reviewed the status of medical genetics and the prospects for a new era of “genomi...
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#1Francis S. Collins (NIH: National Institutes of Health)H-Index: 182
Looking back over the past decade of human genomics, Francis Collins finds five key lessons for the future of personalized medicine — for technology, policy, partnerships and pharmacogenomics.
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#1Adam A. Powell (UMN: University of Minnesota)H-Index: 17
#2Diana J. Burgess (UMN: University of Minnesota)H-Index: 36
Last. Melissa R. Partin (UMN: University of Minnesota)H-Index: 24
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Abstract Objective To assess colorectal cancer (CRC) screening mode preferences and correlates of these preferences among US veterans at average risk for CRC. Method A cross-sectional survey of a nationally representative sample of VA patients was conducted between January 2005 and December 2006. We report preference distributions for screening modes among 2068 average-risk veterans and across patient subgroups based on personal, behavioral, and environmental factors. Independent predictors of p...
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#1Terry L. Wahls (Roy J. and Lucille A. Carver College of Medicine)H-Index: 14
#2Ika Peleg (OU: University of Oklahoma)H-Index: 1
Background A cohort of colorectal cancer (CRC) patients represents an opportunity to study missed opportunities for earlier diagnosis. Primary objective: To study the epidemiology of diagnostic delays and failures to offer/complete CRC screening. Secondary objective: To identify system- and patient-related factors that may contribute to diagnostic delays or failures to offer/complete CRC screening.
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#1Stefania Boccia (UCSC: Catholic University of the Sacred Heart)H-Index: 40
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Whereas medicine is currently undergoing remarkable developments from its morphological and phenotype orientation to a molecular and genotype orientation, promoting the importance of prognosis and prediction, the discussion about the role of genome-based information for epidemiological research and public health still is at the beginning. Public Health Genomics (PHG) contributes to this discussion by focussing on the use of genome-based information for epidemiological research, surveillance syst...
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The authors describe the rationale and initial development of a new collaborative initiative, the Genomic Applications in Practice and Prevention Network. The network convened by the Centers for Disease Control and Prevention and the National Institutes of Health includes multiple stakeholders from academia, government, health care, public health, industry and consumers. The premise of Genomic Applications in Practice and Prevention Network is that there is an unaddressed chasm between gene disc...
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#1Henry T. Lynch (Creighton University)H-Index: 124
#2Patrick M. LynchH-Index: 48
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The estimated annual worldwide incidence of colorectal cancer (CRC) is 1,023,152 (1). Lynch syndrome (LS), previously called hereditary non-polyposis colorectal cancer or HNPCC, accounts, conservatively, for approximately 3% (2) of this incidence (~30,700 cases), compared with familial adenomatous polyposis (FAP) syndrome which is about one-tenth as common, occurring in only about 1 in 10,000 of the population (3,4). Hampel et al. studied 500 tumors from unselected CRC affected individuals. Amon...
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The development of robust and clinically valuable pharmacogenomic tests has been anticipated to be one of the first tangible results of the Human Genome Project. Despite both obvious and unanticipated obstacles, a number of tests have now become available in various practice settings. Lessons can be learned from examination of these tests, the evidence that has catalyzed their use, their value to prescribers, and their merit as tools for personalizing therapeutics.
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#1Patricia GoodsonH-Index: 25
Abstract Purpose This chapter introduces readers to a complex adaptive systems approach for integrating research on genes, behavior, and social structures/institutions. Until recently, scientists have resorted to reductionism as a decoding and epistemological strategy for understanding human health. The complex bonds among health’s biological, behavioral, and social dimensions, however, cannot be fully grasped with reductionist schemas. Moreover, because reducing and simplifying can lead to inco...
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With the human genome project running from 1989 until its completion in 2003, and the incredible advances in sequencing technology and in bioinformatics during the last decade, there has been a shift towards an increase focus on studying common complex disorders which develop due to the interplay of many different genes as well as environmental factors. Although some susceptibility genes have been identified in some populations for disorders such as cancer, diabetes and cardiovascular diseases, ...
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The development of genomic tests is one of the most significant technological advances in medical testing in recent decades. As these tests become increasingly available, so does the need for a pragmatic framework to evaluate the evidence base and evidence gaps in order to facilitate informed decision-making. In this article we describe such a framework that can provide a common language and benchmarks for different stakeholders of genomic testing. Each stakeholder can use this framework to spec...
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