Review paper
Mechanisms of Programmed DNA Lesions and Genomic Instability in the Immune System
Abstract
Chromosomal translocations involving antigen receptor loci are common in lymphoid malignancies. Translocations require DNA double-strand breaks (DSBs) at two chromosomal sites, their physical juxtaposition, and their fusion by end-joining. Ability of lymphocytes to generate diverse repertoires of antigen receptors and effector antibodies derives from programmed genomic alterations that produce DSBs. We discuss these lymphocyte-specific...
Paper Details
Title
Mechanisms of Programmed DNA Lesions and Genomic Instability in the Immune System
Published Date
Jan 1, 2013
Journal
Volume
152
Issue
3
Pages
417 - 429
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