Slit2 as a β-catenin/Ctnnb1-dependent retrograde signal for presynaptic differentiation
Abstract
Neuromuscular junction formation requires proper interaction between motoneurons and muscle cells. β-Catenin (Ctnnb1) in muscle is critical for motoneuron differentiation; however, little is known about the relevant retrograde signal. In this paper, we dissected which functions of muscle Ctnnb1 are critical by an in vivo transgenic approach. We show that Ctnnb1 mutant without the transactivation domain was unable to rescue presynaptic deficits...
Paper Details
Title
Slit2 as a β-catenin/Ctnnb1-dependent retrograde signal for presynaptic differentiation
Published Date
Jul 10, 2015
Journal
Volume
4
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