Effects of Chronic Treatment With l -Arginine on Atherosclerosis in ApoE Knockout and ApoE/Inducible NO Synthase Double-Knockout Mice

Objective— l -Arginine serves as a substrate for the formation of NO by the NO synthase (NOS) enzymes. In some studies, dietary supplementation of l -arginine reduces atherosclerosis through the restoration of NO release and improvement in endothelial function. In the present study, we investigate the effect of l -arginine supplementation on the development of atherosclerosis in a mouse model. Methods and Results— Apolipoprotein E (apoE)...