Match!

Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans

Published on Dec 1, 2014in Diabetes7.20
· DOI :10.2337/db14-0746
Maria Chondronikola13
Estimated H-index: 13
(HUA: Harokopio University),
Elena Volpi54
Estimated H-index: 54
+ 13 AuthorsLambros Sidossis43
Estimated H-index: 43
Abstract
Brown adipose tissue (BAT) has attracted scientific interest as an antidiabetic tissue owing to its ability to dissipate energy as heat. Despite a plethora of data concerning the role of BAT in glucose metabolism in rodents, the role of BAT (if any) in glucose metabolism in humans remains unclear. To investigate whether BAT activation alters whole-body glucose homeostasis and insulin sensitivity in humans, we studied seven BAT-positive (BAT+) men and five BAT-negative (BAT−) men under thermoneutral conditions and after prolonged (5–8 h) cold exposure (CE). The two groups were similar in age, BMI, and adiposity. CE significantly increased resting energy expenditure, whole-body glucose disposal, plasma glucose oxidation, and insulin sensitivity in the BAT+ group only. These results demonstrate a physiologically significant role of BAT in whole-body energy expenditure, glucose homeostasis, and insulin sensitivity in humans, and support the notion that BAT may function as an antidiabetic tissue in humans.
  • References (36)
  • Citations (309)
References36
Newest
#1Mami Matsushita (Tenshi College)H-Index: 13
#2Takeshi Yoneshiro (Hokkaido University)H-Index: 21
Last.Masayuki Saito (Tenshi College)H-Index: 46
view all 6 authors...
131 CitationsSource
#1Janne Orava (TYKS: Turku University Hospital)H-Index: 7
#2Pirjo Nuutila (UTU: University of Turku)H-Index: 64
Last.Kirsi A. Virtanen (TYKS: Turku University Hospital)H-Index: 29
view all 9 authors...
120 CitationsSource
511 CitationsSource
#1Paul R. Lee (NIH: National Institutes of Health)H-Index: 23
#2Robert J. Brychta (NIH: National Institutes of Health)H-Index: 26
Last.Francesco S. Celi (NIH: National Institutes of Health)H-Index: 27
view all 6 authors...
73 CitationsSource
#1Caterina Conte (WashU: Washington University in St. Louis)H-Index: 12
#2Elisa Fabbrini (WashU: Washington University in St. Louis)H-Index: 23
Last.Samuel KleinH-Index: 87
view all 6 authors...
39 CitationsSource
#1Anne-Laure BorelH-Index: 15
#2Julie-Anne NazareH-Index: 17
Last.Jean-Pierre Després (Laval University)H-Index: 118
view all 8 authors...
62 CitationsSource
575 CitationsSource
#1Pontus Boström (Harvard University)H-Index: 23
#2Jun Wu (Harvard University)H-Index: 22
Last.Bruce M. Spiegelman (Harvard University)H-Index: 165
view all 18 authors...
1,711 CitationsSource
#1Janne Orava (UTU: University of Turku)H-Index: 7
#2Pirjo Nuutila (UTU: University of Turku)H-Index: 64
Last.Kirsi A. Virtanen (UTU: University of Turku)H-Index: 29
view all 11 authors...
397 CitationsSource
#1Elayne HondaresH-Index: 17
#2Roser IglesiasH-Index: 34
Last.Francesc VillarroyaH-Index: 40
view all 7 authors...
318 CitationsSource
Cited By309
Newest
#1Brian S. Finlin (UK: University of Kentucky)H-Index: 18
#2Amy L. Confides (UK: University of Kentucky)H-Index: 4
Last.Philip A. Kern (UK: University of Kentucky)H-Index: 54
view all 10 authors...
1 CitationsSource
#1Elizabeth Sanchez-Rangel (Yale University)H-Index: 1
#2Jean-Dominique Gallezot (Yale University)H-Index: 22
Last.Janice J. Hwang (Yale University)H-Index: 5
view all 9 authors...
Source
#1Mikyung Kim Kim (KMU: Keimyung University)
#2So Min LeeH-Index: 1
Last.Eunyoung Ha (KMU: Keimyung University)H-Index: 10
view all 7 authors...
Source
Source
#1Mengle Shao (UTSW: University of Texas Southwestern Medical Center)H-Index: 18
#2Qiong A. Wang (UTSW: University of Texas Southwestern Medical Center)H-Index: 1
Last.Rana K. Gupta (UTSW: University of Texas Southwestern Medical Center)H-Index: 26
view all 7 authors...
Source
#1Hongsuk Park (WashU: Washington University in St. Louis)H-Index: 4
#2Anyuan He (WashU: Washington University in St. Louis)H-Index: 2
Last.Irfan J. Lodhi (WashU: Washington University in St. Louis)H-Index: 19
view all 3 authors...
Source
#1Tomoyuki Nakano (YU: Yamagata University)H-Index: 13
#2Matthew K. Topham (HCI: Huntsman Cancer Institute)H-Index: 34
Last.Kaoru Goto (YU: Yamagata University)H-Index: 27
view all 3 authors...
Source
Source
#1Jie Li (Brown University)H-Index: 1
#2Ran An (Brown University)H-Index: 1
Last.Haiyan Xu (Brown University)
view all 6 authors...
Source
#1Matthias Blüher (Leipzig University)H-Index: 79
Source