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Maria Chondronikola
Washington University in St. Louis
EndocrinologyWhite adipose tissueAdipose tissueBrown adipose tissueDiabetes mellitus
42Publications
13H-index
1,042Citations
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Publications 43
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BACKGROUNDAn increase in intrahepatic triglyceride (IHTG) is the hallmark feature of nonalcoholic fatty liver disease (NAFLD) and is decreased by weight loss. Hepatic de novo lipogenesis (DNL) contributes to steatosis in individuals with NAFLD. The physiological factors that stimulate hepatic DNL and the effect of weight loss on hepatic DNL are not clear.METHODSHepatic DNL, 24-hour integrated plasma insulin and glucose concentrations, and both liver and whole-body insulin sensitivity were determ...
10 CitationsSource
#1Shintaro Yamaguchi (WashU: Washington University in St. Louis)H-Index: 7
#2Michael P. Franczyk (WashU: Washington University in St. Louis)H-Index: 4
Last. Jun Yoshino (WashU: Washington University in St. Louis)H-Index: 20
view all 14 authors...
Nicotinamide adenine dinucleotide (NAD+) is a critical coenzyme for cellular energy metabolism. The aim of the present study was to determine the importance of brown and white adipose tissue (BAT and WAT) NAD+ metabolism in regulating whole-body thermogenesis and energy metabolism. Accordingly, we generated and analyzed adipocyte-specific nicotinamide phosphoribosyltransferase (Nampt) knockout (ANKO) and brown adipocyte-specific Nampt knockout (BANKO) mice because NAMPT is the rate-limiting NAD+...
3 CitationsSource
#1Takeshi Yoneshiro (UCSF: University of California, San Francisco)H-Index: 21
#2Qiang Wang (UCSF: University of California, San Francisco)H-Index: 3
Last. Shingo Kajimura (UCSF: University of California, San Francisco)H-Index: 43
view all 36 authors...
Branched-chain amino acid (BCAA; valine, leucine and isoleucine) supplementation is often beneficial to energy expenditure; however, increased circulating levels of BCAA are linked to obesity and diabetes. The mechanisms of this paradox remain unclear. Here we report that, on cold exposure, brown adipose tissue (BAT) actively utilizes BCAA in the mitochondria for thermogenesis and promotes systemic BCAA clearance in mice and humans. In turn, a BAT-specific defect in BCAA catabolism attenuates sy...
31 CitationsSource
#1Maria Chondronikola (UoA: National and Kapodistrian University of Athens)H-Index: 13
#2Lambros Sidossis (RU: Rutgers University)H-Index: 43
Abstract The recent re-discovery of brown adipose tissue (BAT) and even more recent discovery of the browning of white adipose tissue (WAT) in humans have generated intense scientific interest in the role of adipose tissue as potential target against obesity and its metabolic complications. The purpose of this review is to: i) critically evaluate the current evidence on the physiological significance of BAT and the browning of WAT in metabolic function in humans and ii) discuss factors that have...
6 CitationsSource
#1Constantina Papoutsakis (UoA: National and Kapodistrian University of Athens)H-Index: 17
#2Eleni Papadakou (UoA: National and Kapodistrian University of Athens)H-Index: 1
Last. Kostas N. Priftis (UoA: National and Kapodistrian University of Athens)H-Index: 27
view all 8 authors...
Purpose Lifestyle (diet and physical activity) may increase asthma risk, but evidence in this area is lacking. The aims of the present study were to calculate an obesity-preventive lifestyle score comprising of eating and physical activity behaviors and investigate the overall effect of lifestyle on asthma in children.
Source
#1Maria Chondronikola (Atkins)H-Index: 13
#2Faidon Magkos (Agency for Science, Technology and Research)H-Index: 43
Last. Samuel Klein (Atkins)H-Index: 87
view all 8 authors...
OBJECTIVE: Lactate is an intermediate of glucose metabolism that has been implicated in the pathogenesis of insulin resistance. This study evaluated the relationship between glucose kinetics and plasma lactate concentration ([LAC]) before and after manipulating insulin sensitivity by progressive weight loss. METHODS: Forty people with obesity (BMI = 37.9 ± 4.3 kg/m2 ) were randomized to weight maintenance (n = 14) or weight loss (n = 19). Subjects were studied before and after 6 months of weight...
5 CitationsSource
#1Maria Chondronikola (WashU: Washington University in St. Louis)H-Index: 13
#2Scott C. Beeman (WashU: Washington University in St. Louis)H-Index: 12
Last. Richard L. Wahl (WashU: Washington University in St. Louis)H-Index: 85
view all 3 authors...
Brown adipose tissue (BAT) is a recently rediscovered tissue in people that has shown promise as a potential therapeutic target against obesity and its metabolic abnormalities. Reliable non-invasive assessment of BAT volume and activity is critical to allow its importance in metabolic control to be evaluated. Positron emission tomography/computed tomography (PET/CT) in combination with 2-deoxy-2-[18 F]fluoroglucose administration is currently the most frequently used and most established method ...
15 CitationsSource
#1Rabia Asghar (UTMB: University of Texas Medical Branch)H-Index: 1
#2Maria Chondronikola (UTMB: University of Texas Medical Branch)H-Index: 13
Last. Demidmaa TuvdendorjH-Index: 11
view all 15 authors...
: Intramyocellular triglyceride (imTG) in skeletal muscle plays a significant role in metabolic health, and an infusion of [13C16]palmitate can be used to quantitate the in vivo fractional synthesis rate (FSR) and absolute synthesis rate (ASR) of imTGs. However, the extramyocellular TG (emTG) pool, unless precisely excised, contaminates the imTG pool, diluting the imTG-bound tracer enrichment and leading to underestimation of FSR. Because of the difficulty of excising the emTGs precisely, it wou...
Source
#1Maria Chondronikola (UTMB: University of Texas Medical Branch)H-Index: 13
#2Rabia Asghar (UTMB: University of Texas Medical Branch)H-Index: 1
Last. Demidmaa Tuvdendorj (UTMB: University of Texas Medical Branch)H-Index: 11
view all 15 authors...
Summary Background Circulating acyl-carnitines (acyl-CNTs) are associated with insulin resistance (IR) and type 2 diabetes (T2D) in both rodents and humans. However, the mechanisms whereby circulating acyl-CNTs are increased in these conditions and their role in whole-body metabolism remains unknown. The purpose of this study was to determine if, in humans, blood cells contribute in production of circulating acyl-CNTs and associate with whole-body fat metabolism. Methods and results Eight non-di...
1 CitationsSource
OBJECTIVE: Brown adipose tissue (BAT) has been proposed as a potential therapeutic target against obesity and its related metabolic conditions. Data from studies in rodents support a cross talk between BAT and other distal tissues. The relation between BAT and peptide hormones secreted from the gastrointestinal system (GI) and involved in appetite regulation is not known in humans. DESIGN: We studied 18 men during thermoneutral conditions and mild non-shivering cold exposure (CE). METHODS: 2-Deo...
5 CitationsSource
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