Original paper
Lactate racemase is a nickel-dependent enzyme activated by a widespread maturation system
Abstract
Racemases catalyse the inversion of stereochemistry in biological molecules, giving the organism the ability to use both isomers. Among them, lactate racemase remains unexplored due to its intrinsic instability and lack of molecular characterization. Here we determine the genetic basis of lactate racemization in Lactobacillus plantarum. We show that, unexpectedly, the racemase is a nickel-dependent enzyme with a novel α/β fold. In addition, we...
Paper Details
Title
Lactate racemase is a nickel-dependent enzyme activated by a widespread maturation system
Published Date
Apr 7, 2014
Journal
Volume
5
Issue
1
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Notes
History