A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians

Yoichiro Kamatani; Sukanya Wattanapokayakit; Hidenori Ochi; Takahisa Kawaguchi; Atsushi Takahashi; Naoya Hosono; Michiaki Kubo; Tatsuhiko Tsunoda; Naoyuki Kamatani; Hiromitsu Kumada; Yusuke Nakamura; Koichi Matsuda

doi:https://doi.org/10.1038/ng.348

doi.org/10.1038/ng.348

A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians

Yoichiro Kamatani

55

,

Sukanya Wattanapokayakit

13

,

..., Koichi Matsuda

64

Nature Genetics30.80

Volume: 41, Issue: 5, Pages: 591 - 595

Published: Apr 6, 2009

Abstract

Chronic hepatitis B is a serious infectious liver disease that often progresses to liver cirrhosis and hepatocellular carcinoma; however, clinical outcomes after viral exposure vary enormously among individuals. Through a two-stage genome-wide association study using 786 Japanese chronic hepatitis B cases and 2,201 controls, we identified a significant association of chronic hepatitis B with 11 SNPs in a region including HLA-DPA1 and HLA-DPB1....

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Paper Details

Title

A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians

DOI

doi.org/10.1038/ng.348

Published Date

Apr 6, 2009

Journal

Nature Genetics

Volume

41

Issue

5

Pages

591 - 595

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