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Overview and Frontier for the Development of Metallopharmaceutics

Published on Jan 1, 2010in Journal of Health Science
· DOI :10.1248/jhs.56.129
Hiromu Sakurai12
Estimated H-index: 12
(Suzuka University of Medical Science)
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Abstract
This review introduces the development of metal-containing pharmaceutics (metallopharmaceutics) such as anticancer agents containing platinum (Pt) and ruthenium (Ru), and superoxide dismutase (SOD) mimetic, focusing on the recent topics on antidiabetic vanadium (V) and zinc (Zn) complexes as well as antioxidative copper (Cu) and Zn complexes. From the ancient ages, people used many types of inorganic compounds to treat physical disorders or diseases. Since the modern concept of chemotherapy was achieved by Paul Ehrlich, who developed the arsenic (As)-containing compound to treat syphilis in 1910, a wide variety of metallopharmaceutics have been proposed and clinically used worldwide. This review is described for the researchers who are interested in the current states for the development of metallopharmaceutics.
  • References (58)
  • Citations (16)
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References58
Newest
Published on Jan 1, 2009in Metallomics3.57
George J. Brewer61
Estimated H-index: 61
(UM: University of Michigan)
Wilson’s disease, an autosomal recessive disease of copper accumulation and copper toxicity primarily in the liver and brain, has been the engine that has driven the development of anticopper drugs. Here we first briefly review Wilson’s disease, then review the four anticopper drugs used to treat Wilson’s disease. We then discuss the results of therapy with anticopper drugs in Wilson’s disease, with special emphasis on the newer and better drugs, zinc and tetrathiomolybdate. We then discuss new ...
Published on Jan 1, 2009in Metallomics3.57
Makoto Hiromura15
Estimated H-index: 15
(Kyoto Pharmaceutical University),
Yusuke Adachi21
Estimated H-index: 21
(Kyoto Pharmaceutical University)
+ 2 AuthorsHiromu Sakurai48
Estimated H-index: 48
(Kyoto Pharmaceutical University)
Vanadyl(IV) complexes are anti-diabetogenic agents. Intra-peritoneal administration of bis(allixinato)oxidovanadium(IV) [VO(alx)2] lowers high blood glucose levels in animal models of type 1 and type 2 diabetes. We have examined whether oral administration of VO(alx)2 restores impaired activation in signaling cascades related to glucose metabolism and insulin action, and alters gene expression in the skeletal muscles of streptozotocin (STZ)-induced diabetic mice (STZ-diabetic mice). We report he...
Published on Jan 1, 2009in Metallomics3.57
Aviva Levina30
Estimated H-index: 30
(USYD: University of Sydney),
Anannya Mitra3
Estimated H-index: 3
(USYD: University of Sydney),
Peter A. Lay45
Estimated H-index: 45
(USYD: University of Sydney)
Interest in Ru anticancer drugs has been growing rapidly since NAMI-A ((ImH+)[RuIIICl4(Im)(S-dmso)], where Im = imidazole and S-dmso = S-bound dimethylsulfoxide) or KP1019 ((IndH+)[RuIIICl4(Ind)2], where Ind = indazole) have successfully completed phase I clinical trials and an array of other Ru complexes have shown promise for future development. Herein, the recent literature is reviewed critically to ascertain likely mechanisms of action of Ru-based anticancer drugs, with the emphasis on their...
Published on Jan 1, 2009in Metallomics3.57
Ryan C. Todd5
Estimated H-index: 5
(MIT: Massachusetts Institute of Technology),
Stephen J. Lippard116
Estimated H-index: 116
(MIT: Massachusetts Institute of Technology)
Cisplatin, carboplatin, and oxaliplatin are three FDA-approved members of the platinum anticancer drug family. These compounds induce apoptosis in tumor cells by binding to nuclear DNA, forming a variety of structural adducts and triggering cellular responses, one of which is the inhibition of transcription. In this report we present (i) a detailed review of the structural investigations of various Pt–DNA adducts and the effects of these lesions on global DNA geometry; (ii) research detailing in...
Published on Oct 1, 2008in Rejuvenation Research3.81
Tamás Radovits20
Estimated H-index: 20
(Heidelberg University),
Domokos Gero16
Estimated H-index: 16
(Semmelweis University)
+ 6 AuthorsGábor Szabó32
Estimated H-index: 32
(Heidelberg University)
Abstract Background: Aging-associated nitro-oxidative stress causes tissue injury and activates proinflammatory pathways that play an important role in the pathogenesis of aging-associated cardiovascular dysfunction. It has been recently reported, that the copper(II)–aspirinate complex (CuAsp) exerts not only the well-known anti-inflammatory and platelet antiaggregating effects of aspirin, but, due to its superoxide dismutase mimetic activity, it acts as a potent antioxidant as well. In this stu...
Published on Jul 1, 2008in Journal of Organometallic Chemistry2.07
Nicholas C. Lloyd5
Estimated H-index: 5
(University of Waikato),
Hugh W. Morgan16
Estimated H-index: 16
(University of Waikato)
+ 1 AuthorsRon S. Ronimus19
Estimated H-index: 19
(University of Waikato)
Full NMR and ESI-MS spectra, and differential scanning calorimeter data are presented for 15 substituted phenylarsonic acids, including two new fluoro-substituted examples. X-ray crystal structure determinations of five examples (phenylarsonic acid and the 4-fluoro-, 4-fluoro-3-nitro-, 3-amino-4-hydroxy- and 3-amino-4-methoxy-substituted derivatives) were determined and the H-bonding crystal-packing patterns analysed.
Published on Jun 1, 2008in Journal of Biological Inorganic Chemistry3.63
Akihiro Nakayama8
Estimated H-index: 8
(Kyoto Pharmaceutical University),
Makoto Hiromura15
Estimated H-index: 15
(Kyoto Pharmaceutical University)
+ 1 AuthorsHiromu Sakurai48
Estimated H-index: 48
(Kyoto Pharmaceutical University)
We previously reported new zinc complexes of allixin [bis(allixinato)zinc] and its derivative bis(thioallixin-N-methyl)zinc that demonstrated excellent antidiabetic activity in type 2 diabetic mellitus KKAy mice. However, the molecular mechanism of these complexes is not fully understood. Thus, we attempted to reveal the intracellular mechanism of these complexes in 3T3-L1 adipocytes. Both zinc complexes induced Akt/protein kinase B (Akt/PKB) phosphorylation. The phosphorylation of Akt/PKB enhan...
Joshua W. Pyatskowit5
Estimated H-index: 5
(UMN: University of Minnesota),
Joseph R. Prohaska36
Estimated H-index: 36
(UMN: University of Minnesota)
Iron homeostasis depends on adequate dietary copper but the mechanisms are unknown. Mice (Mus musculus) and rat (Rattus norvegicus) offspring were compared to determine the effect of dietary copper deficiency (Cu−) on iron status of plasma, liver, brain and intestine. Holtzman rat and Hsd:ICR (CD-1) outbred albino mouse dams were fed a Cu− diet and drank deionized water or Cu supplemented water. Offspring were sampled at time points between postnatal ages 13 and 32. Cu− rat and mouse pups were b...
Published on Apr 1, 2008in International Journal of Cosmetic Science1.48
Yasunobu Ochiai4
Estimated H-index: 4
,
Satoko Kaburagi3
Estimated H-index: 3
+ 4 AuthorsHiromu Sakurai48
Estimated H-index: 48
(Kyoto Pharmaceutical University)
Synopsis Oxidative stress caused by ultraviolet (UV) radiation generates reactive oxygen species (ROS) in the skin, induces the secretion of melanocyte growth and activating factors from keratinocytes, which results in the formation of cutaneous hyper-pigmentation. Thus, increasing the anti-oxidative ability of skin cells is expected to be a good strategy for skin-lightening cosmetics. Metallothionein (MT) is one of the stress-induced proteins and is known to exhibit a strong anti-oxidative prop...
Published on Jan 1, 2008in Chemical Society Reviews40.44
Hiromu Sakurai12
Estimated H-index: 12
(Suzuka University of Medical Science),
Yutaka Yoshikawa27
Estimated H-index: 27
(Kyoto Pharmaceutical University),
Hiroyuki Yasui31
Estimated H-index: 31
(Kyoto Pharmaceutical University)
This tutorial review introduces the current state of metallopharmaceutics development by focusing on the topics of anti-diabetic vanadium and zinc complexes. Over thousands of years, people have produced many types of inorganic compounds, and the modern concept of chemotherapy was achieved by Ehrlich, who used an arsenic-containing compound to treat syphilis. Since then, many metallopharmaceutics have been developed worldwide. This review will be helpful to researchers who are interested in the ...
Cited By16
Newest
Published on Nov 1, 2018in Biological Trace Element Research2.43
Deepika Tripathi2
Estimated H-index: 2
(NDRI: National Dairy Research Institute),
Veena Mani6
Estimated H-index: 6
(NDRI: National Dairy Research Institute),
Ravi Prakash Pal2
Estimated H-index: 2
(NDRI: National Dairy Research Institute)
Ultra-trace elements or occasionally beneficial elements (OBE) are the new categories of minerals including vanadium (V). The importance of V is attributed due to its multifaceted biological roles, i.e., glucose and lipid metabolism as an insulin-mimetic, antilipemic and a potent stress alleviating agent in diabetes when vanadium is administered at lower doses. It competes with iron for transferrin (binding site for transportation) and with lactoferrin as it is secreted in milk also. The intrace...
Published on Sep 1, 2018in Polyhedron2.28
Miroslava Puchoňová4
Estimated H-index: 4
(STU: Slovak University of Technology in Bratislava),
Simona Matejová1
Estimated H-index: 1
(STU: Slovak University of Technology in Bratislava)
+ 5 AuthorsDušan Valigura15
Estimated H-index: 15
Abstract Two new salicylatocopper(II) complexes of formula [Cu(3-Mesal) 2 (inia) 2 ] 2 1 and [Cu(4-MeOsal) 2 (H 2 O)]·H 2 O 2 , (where 3-Mesal = 3-methylsalicylate, inia = isonicotinamide, 4-MeOsal = 4-methoxylsalicylate) have been studied in solid state or in solutions. The coordination environment of compound 1 differs from complex 2 , but both compounds build up 2-D supramolecular framework. The spectral and magnetic properties are in good agreement to their structure. Moreover, the cyclic vo...
Slobodan Novokmet3
Estimated H-index: 3
,
Isidora Stojic2
Estimated H-index: 2
+ 2 AuthorsJovana Jeremic3
Estimated H-index: 3
Published on Jan 1, 2017in Inorganica Chimica Acta2.43
Miroslava Puchoňová4
Estimated H-index: 4
,
Jozef Švorec9
Estimated H-index: 9
+ 6 AuthorsDušan Valigura15
Estimated H-index: 15
Abstract Four new methylsalicylato copper(II) complexes with formula [Cu(4-Mesal) 2 (2-Meim) 2 ] ( 1 ), [Cu(4-Mesal) 2 (im) 2 ] ( 2 ), [Cu(3-Mesal) 2 (bzim) 2 ]·2H 2 O ( 3 ), [Cu(5-Mesal) 2 (im) 2 ] n ( 4 ) (where 3-Mesal − = 3-methylsalicylato, 4-Mesal − = 4-methylsalicylato, 5-Mesal − = 5-methylsalicylato anion, im = imidazole, 2-Meim = 2-methylimidazole and bzim = benzimidazole) are reported. The solid state complexes were characterized by IR, UV–Vis, EPR, X-ray and magnetic measurements. Des...
Published on May 1, 2015in Journal of Luminescence2.96
Banabithi Koley Seth4
Estimated H-index: 4
(SINP: Saha Institute of Nuclear Physics),
Aurkie Ray4
Estimated H-index: 4
(SINP: Saha Institute of Nuclear Physics),
Samita Basu16
Estimated H-index: 16
(SINP: Saha Institute of Nuclear Physics)
Abstract The structural effects of different copper(II) and nickel(II) Schiff base complexes on hen egg white lysozyme (HEWL) have been investigated through steady state and time resolved absorption and fluorescence, and circular dichroism spectroscopy. The Schiff base ligands with N 4 donor atoms show both hydrophobic and hydrophilic interactions, however hydrophilic interaction prevails with ligands having N 2 O 2 donor atoms. Variation of metal ions from Cu 2+ to Ni 2+ with each type of Schif...
Published on Jun 24, 2014in Metallomics3.57
Banabithi Koley Seth4
Estimated H-index: 4
(SINP: Saha Institute of Nuclear Physics),
Aurkie Ray4
Estimated H-index: 4
(SINP: Saha Institute of Nuclear Physics)
+ 1 AuthorsSamita Basu16
Estimated H-index: 16
(SINP: Saha Institute of Nuclear Physics)
The engineering of protein–small molecule interactions becomes imperative today to recognize the essential biochemical processes in living systems. Here we have investigated the interaction between hen egg white lysozyme (HEWL) and a newly synthesized small, simple nickel Schiff base complex (NSC) {(N1E,N2E)-N1,N2-bis(pyridine-2-ylmethylene)propane-1,2-diaminenickel(II)} using different spectroscopic techniques. We attempted to determine the exact site of the interaction by crystallography. Abso...
Sze Koon Lee4
Estimated H-index: 4
(UM: University of Malaya),
Kong Wai Tan9
Estimated H-index: 9
(UM: University of Malaya)
+ 3 AuthorsAkim Abdah1
Estimated H-index: 1
(UPM: Universiti Putra Malaysia)
Abstract A cationic Schiff base ligand, TSB ( L ) and its Zn (II) complex ( 1 ) were synthesized and characterized by using CHN, 1 H-NMR, FT-IR, UV, LC–MS, and X-ray methods. Their ability to inhibit topoisomerase I, DNA cleavage activities, and cytotoxicity were studied. X-ray diffraction study shows that the mononuclear complex 1 is four coordinated with distorted tetrahedral geometry. The singly deprotonated Schiff base ligand L acts as a bidentate ON-donor ligand. Complexation of L increases...
Published on Jan 1, 2013in Dalton Transactions4.05
Abeer Al-Qatati3
Estimated H-index: 3
(CSU: Colorado State University),
Fabio L. Fontes5
Estimated H-index: 5
(CSU: Colorado State University)
+ 3 AuthorsDebbie C. Crans48
Estimated H-index: 48
(CSU: Colorado State University)
Vanadium oxides (VOs) have been identified as low molecular weight sensitizing agents associated with occupational asthma and compromised pulmonary immunocompetence. Symptoms of adult onset asthma result, in part, from increased signal transduction by Type I Fce receptors (FceRI) leading to release of vasoactive compounds including histamine from mast cells. Exposure to (VOs) typically occurs in the form of particles which are insoluble. Upon contact with water or biological fluids, (VOs) form a...
Published on Jan 1, 2013in Polyhedron2.28
Hanna Pruchnik10
Estimated H-index: 10
(Wroclaw University of Environmental and Life Sciences),
Małgorzata Latocha12
Estimated H-index: 12
(Medical University of Silesia)
+ 2 AuthorsFlorian P. Pruchnik18
Estimated H-index: 18
(UWr: University of Wrocław)
Abstract Butyltin complexes with 5-sulfosalicylic acid (H 3 ssal) [Sn(C 4 H 9 ) 3 {O 3 SC 6 H 3 (OH)COOH}] ( 1 ), [Sn 2 (C 4 H 9 ) 6 (OOCC 6 H 3 OHSO 3 )] ( 2 ) and [Sn 3 (C 4 H 9 ) 6 (OOCC 6 H 3 (OH)SO 3 ) 2 O] ( 3 ) have been synthesized and characterized by ESI-MS, IR and 1 H, 13 C and 119 Sn NMR spectra. Their structures and properties in solid state and solutions were proposed on the basis of the spectroscopic data and density functional theory (DFT) calculations at B3LYP/3-21G ∗∗ level. Th...
Pa Arunkumar2
Estimated H-index: 2
,
Gl Viswanatha1
Estimated H-index: 1
+ 2 AuthorsBelliyappa2
Estimated H-index: 2
(St. John's Medical College)
Objective To investigate the relationship between serum electrolyte changes and cisplatin induced nephrotoxicity.
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