Overview and Frontier for the Development of Metallopharmaceutics

Published on Jan 1, 2010in Journal of Health Science
· DOI :10.1248/jhs.56.129
Hiromu Sakurai12
Estimated H-index: 12
(Suzuka University of Medical Science)
This review introduces the development of metal-containing pharmaceutics (metallopharmaceutics) such as anticancer agents containing platinum (Pt) and ruthenium (Ru), and superoxide dismutase (SOD) mimetic, focusing on the recent topics on antidiabetic vanadium (V) and zinc (Zn) complexes as well as antioxidative copper (Cu) and Zn complexes. From the ancient ages, people used many types of inorganic compounds to treat physical disorders or diseases. Since the modern concept of chemotherapy was achieved by Paul Ehrlich, who developed the arsenic (As)-containing compound to treat syphilis in 1910, a wide variety of metallopharmaceutics have been proposed and clinically used worldwide. This review is described for the researchers who are interested in the current states for the development of metallopharmaceutics.
  • References (58)
  • Citations (16)
📖 Papers frequently viewed together
1 Author (Nicholas Farrell)
99 Citations
4 Citations
48 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
#1Aviva Levina (USYD: University of Sydney)H-Index: 31
#2Anannya Mitra (USYD: University of Sydney)H-Index: 3
Last. Peter A. Lay (USYD: University of Sydney)H-Index: 45
view all 3 authors...
Interest in Ru anticancer drugs has been growing rapidly since NAMI-A ((ImH+)[RuIIICl4(Im)(S-dmso)], where Im = imidazole and S-dmso = S-bound dimethylsulfoxide) or KP1019 ((IndH+)[RuIIICl4(Ind)2], where Ind = indazole) have successfully completed phase I clinical trials and an array of other Ru complexes have shown promise for future development. Herein, the recent literature is reviewed critically to ascertain likely mechanisms of action of Ru-based anticancer drugs, with the emphasis on their...
341 CitationsSource
#1Ryan C. Todd (MIT: Massachusetts Institute of Technology)H-Index: 5
#2Stephen J. Lippard (MIT: Massachusetts Institute of Technology)H-Index: 119
Cisplatin, carboplatin, and oxaliplatin are three FDA-approved members of the platinum anticancer drug family. These compounds induce apoptosis in tumor cells by binding to nuclear DNA, forming a variety of structural adducts and triggering cellular responses, one of which is the inhibition of transcription. In this report we present (i) a detailed review of the structural investigations of various Pt–DNA adducts and the effects of these lesions on global DNA geometry; (ii) research detailing in...
324 CitationsSource
#1George J. Brewer (UM: University of Michigan)H-Index: 62
Wilson’s disease, an autosomal recessive disease of copper accumulation and copper toxicity primarily in the liver and brain, has been the engine that has driven the development of anticopper drugs. Here we first briefly review Wilson’s disease, then review the four anticopper drugs used to treat Wilson’s disease. We then discuss the results of therapy with anticopper drugs in Wilson’s disease, with special emphasis on the newer and better drugs, zinc and tetrathiomolybdate. We then discuss new ...
34 CitationsSource
#1Makoto Hiromura (Kyoto Pharmaceutical University)H-Index: 14
#2Yusuke Adachi (Kyoto Pharmaceutical University)H-Index: 21
Last. Hiromu Sakurai (Kyoto Pharmaceutical University)H-Index: 50
view all 5 authors...
Vanadyl(IV) complexes are anti-diabetogenic agents. Intra-peritoneal administration of bis(allixinato)oxidovanadium(IV) [VO(alx)2] lowers high blood glucose levels in animal models of type 1 and type 2 diabetes. We have examined whether oral administration of VO(alx)2 restores impaired activation in signaling cascades related to glucose metabolism and insulin action, and alters gene expression in the skeletal muscles of streptozotocin (STZ)-induced diabetic mice (STZ-diabetic mice). We report he...
21 CitationsSource
#1Hiromu Sakurai (Suzuka University of Medical Science)H-Index: 12
#2Yutaka Yoshikawa (Kyoto Pharmaceutical University)H-Index: 28
Last. Hiroyuki Yasui (Kyoto Pharmaceutical University)H-Index: 32
view all 3 authors...
This tutorial review introduces the current state of metallopharmaceutics development by focusing on the topics of anti-diabetic vanadium and zinc complexes. Over thousands of years, people have produced many types of inorganic compounds, and the modern concept of chemotherapy was achieved by Ehrlich, who used an arsenic-containing compound to treat syphilis. Since then, many metallopharmaceutics have been developed worldwide. This review will be helpful to researchers who are interested in the ...
110 CitationsSource
#1Tamás Radovits (Heidelberg University)H-Index: 21
#2Domokos Gero (Semmelweis University)H-Index: 22
Last. Gábor Szabó (Heidelberg University)H-Index: 32
view all 9 authors...
Abstract Background: Aging-associated nitro-oxidative stress causes tissue injury and activates proinflammatory pathways that play an important role in the pathogenesis of aging-associated cardiovascular dysfunction. It has been recently reported, that the copper(II)–aspirinate complex (CuAsp) exerts not only the well-known anti-inflammatory and platelet antiaggregating effects of aspirin, but, due to its superoxide dismutase mimetic activity, it acts as a potent antioxidant as well. In this stu...
13 CitationsSource
#1Nicholas C. Lloyd (University of Waikato)H-Index: 5
#2Hugh W. Morgan (University of Waikato)H-Index: 17
Last. Ron S. Ronimus (University of Waikato)H-Index: 23
view all 4 authors...
Full NMR and ESI-MS spectra, and differential scanning calorimeter data are presented for 15 substituted phenylarsonic acids, including two new fluoro-substituted examples. X-ray crystal structure determinations of five examples (phenylarsonic acid and the 4-fluoro-, 4-fluoro-3-nitro-, 3-amino-4-hydroxy- and 3-amino-4-methoxy-substituted derivatives) were determined and the H-bonding crystal-packing patterns analysed.
12 CitationsSource
#1Yasunobu OchiaiH-Index: 3
#2Satoko KaburagiH-Index: 3
Last. Hiromu Sakurai (Kyoto Pharmaceutical University)H-Index: 50
view all 7 authors...
Synopsis Oxidative stress caused by ultraviolet (UV) radiation generates reactive oxygen species (ROS) in the skin, induces the secretion of melanocyte growth and activating factors from keratinocytes, which results in the formation of cutaneous hyper-pigmentation. Thus, increasing the anti-oxidative ability of skin cells is expected to be a good strategy for skin-lightening cosmetics. Metallothionein (MT) is one of the stress-induced proteins and is known to exhibit a strong anti-oxidative prop...
12 CitationsSource
#1Joshua W. Pyatskowit (UMN: University of Minnesota)H-Index: 5
#2Joseph R. Prohaska (UMN: University of Minnesota)H-Index: 37
Iron homeostasis depends on adequate dietary copper but the mechanisms are unknown. Mice (Mus musculus) and rat (Rattus norvegicus) offspring were compared to determine the effect of dietary copper deficiency (Cu−) on iron status of plasma, liver, brain and intestine. Holtzman rat and Hsd:ICR (CD-1) outbred albino mouse dams were fed a Cu− diet and drank deionized water or Cu supplemented water. Offspring were sampled at time points between postnatal ages 13 and 32. Cu− rat and mouse pups were b...
29 CitationsSource
#1Akihiro Nakayama (Kyoto Pharmaceutical University)H-Index: 8
#2Makoto Hiromura (Kyoto Pharmaceutical University)H-Index: 14
Last. Hiromu Sakurai (Kyoto Pharmaceutical University)H-Index: 50
view all 4 authors...
We previously reported new zinc complexes of allixin [bis(allixinato)zinc] and its derivative bis(thioallixin-N-methyl)zinc that demonstrated excellent antidiabetic activity in type 2 diabetic mellitus KKAy mice. However, the molecular mechanism of these complexes is not fully understood. Thus, we attempted to reveal the intracellular mechanism of these complexes in 3T3-L1 adipocytes. Both zinc complexes induced Akt/protein kinase B (Akt/PKB) phosphorylation. The phosphorylation of Akt/PKB enhan...
46 CitationsSource
Cited By16
#1Miroslava Puchoňová (STU: Slovak University of Technology in Bratislava)H-Index: 4
#2Simona Matejová (STU: Slovak University of Technology in Bratislava)H-Index: 1
Last. Dušan ValiguraH-Index: 15
view all 8 authors...
Abstract Two new salicylatocopper(II) complexes of formula [Cu(3-Mesal)2(inia)2]2 1 and [Cu(4-MeOsal)2(H2O)]·H2O 2, (where 3-Mesal = 3-methylsalicylate, inia = isonicotinamide, 4-MeOsal = 4-methoxylsalicylate) have been studied in solid state or in solutions. The coordination environment of compound 1 differs from complex 2, but both compounds build up 2-D supramolecular framework. The spectral and magnetic properties are in good agreement to their structure. Moreover, the cyclic voltammetric st...
3 CitationsSource
#1Deepika Tripathi (NDRI: National Dairy Research Institute)H-Index: 3
#2Veena Mani (NDRI: National Dairy Research Institute)H-Index: 6
Last. Ravi Prakash Pal (NDRI: National Dairy Research Institute)H-Index: 3
view all 3 authors...
Ultra-trace elements or occasionally beneficial elements (OBE) are the new categories of minerals including vanadium (V). The importance of V is attributed due to its multifaceted biological roles, i.e., glucose and lipid metabolism as an insulin-mimetic, antilipemic and a potent stress alleviating agent in diabetes when vanadium is administered at lower doses. It competes with iron for transferrin (binding site for transportation) and with lactoferrin as it is secreted in milk also. The intrace...
3 CitationsSource
#2Jozef ŠvorecH-Index: 9
Last. Dušan ValiguraH-Index: 15
view all 9 authors...
Abstract Four new methylsalicylato copper(II) complexes with formula [Cu(4-Mesal) 2 (2-Meim) 2 ] ( 1 ), [Cu(4-Mesal) 2 (im) 2 ] ( 2 ), [Cu(3-Mesal) 2 (bzim) 2 ]·2H 2 O ( 3 ), [Cu(5-Mesal) 2 (im) 2 ] n ( 4 ) (where 3-Mesal − = 3-methylsalicylato, 4-Mesal − = 4-methylsalicylato, 5-Mesal − = 5-methylsalicylato anion, im = imidazole, 2-Meim = 2-methylimidazole and bzim = benzimidazole) are reported. The solid state complexes were characterized by IR, UV–Vis, EPR, X-ray and magnetic measurements. Des...
9 CitationsSource
#1Banabithi Koley Seth (SINP: Saha Institute of Nuclear Physics)H-Index: 4
#2Aurkie Ray (SINP: Saha Institute of Nuclear Physics)H-Index: 4
Last. Samita Basu (SINP: Saha Institute of Nuclear Physics)H-Index: 17
view all 3 authors...
The structural effects of different copper(II) and nickel(II) Schiff base complexes on hen egg white lysozyme (HEWL) have been investigated through steady state and time resolved absorption and fluorescence, and circular dichroism spectroscopy. The Schiff base ligands with N4 donor atoms show both hydrophobic and hydrophilic interactions, however hydrophilic interaction prevails with ligands having N2O2 donor atoms. Variation of metal ions from Cu2+ to Ni2+ with each type of Schiff base ligand i...
2 CitationsSource
#1Banabithi Koley Seth (SINP: Saha Institute of Nuclear Physics)H-Index: 4
#2Aurkie Ray (SINP: Saha Institute of Nuclear Physics)H-Index: 4
Last. Samita Basu (SINP: Saha Institute of Nuclear Physics)H-Index: 17
view all 4 authors...
The engineering of protein–small molecule interactions becomes imperative today to recognize the essential biochemical processes in living systems. Here we have investigated the interaction between hen egg white lysozyme (HEWL) and a newly synthesized small, simple nickel Schiff base complex (NSC) {(N1E,N2E)-N1,N2-bis(pyridine-2-ylmethylene)propane-1,2-diaminenickel(II)} using different spectroscopic techniques. We attempted to determine the exact site of the interaction by crystallography. Abso...
4 CitationsSource
#1Sze Koon Lee (UM: University of Malaya)H-Index: 4
#2Kong Wai Tan (UM: University of Malaya)H-Index: 9
Last. Akim Abdah (UPM: Universiti Putra Malaysia)H-Index: 1
view all 6 authors...
Abstract A cationic Schiff base ligand, TSB (L) and its Zn (II) complex (1) were synthesized and characterized by using CHN, 1H-NMR, FT-IR, UV, LC–MS, and X-ray methods. Their ability to inhibit topoisomerase I, DNA cleavage activities, and cytotoxicity were studied. X-ray diffraction study shows that the mononuclear complex 1 is four coordinated with distorted tetrahedral geometry. The singly deprotonated Schiff base ligand L acts as a bidentate ON-donor ligand. Complexation of L increases the ...
14 CitationsSource
#1Abeer Al-Qatati (CSU: Colorado State University)H-Index: 4
#2Fabio L. Fontes (CSU: Colorado State University)H-Index: 5
Last. Debbie C. Crans (CSU: Colorado State University)H-Index: 49
view all 6 authors...
Vanadium oxides (VOs) have been identified as low molecular weight sensitizing agents associated with occupational asthma and compromised pulmonary immunocompetence. Symptoms of adult onset asthma result, in part, from increased signal transduction by Type I Fce receptors (FceRI) leading to release of vasoactive compounds including histamine from mast cells. Exposure to (VOs) typically occurs in the form of particles which are insoluble. Upon contact with water or biological fluids, (VOs) form a...
6 CitationsSource
#1Hanna Pruchnik (Wroclaw University of Environmental and Life Sciences)H-Index: 11
#2Małgorzata Latocha (Medical University of Silesia)H-Index: 11
Last. Florian P. Pruchnik (UWr: University of Wrocław)H-Index: 19
view all 5 authors...
Abstract Butyltin complexes with 5-sulfosalicylic acid (H 3 ssal) [Sn(C 4 H 9 ) 3 {O 3 SC 6 H 3 (OH)COOH}] ( 1 ), [Sn 2 (C 4 H 9 ) 6 (OOCC 6 H 3 OHSO 3 )] ( 2 ) and [Sn 3 (C 4 H 9 ) 6 (OOCC 6 H 3 (OH)SO 3 ) 2 O] ( 3 ) have been synthesized and characterized by ESI-MS, IR and 1 H, 13 C and 119 Sn NMR spectra. Their structures and properties in solid state and solutions were proposed on the basis of the spectroscopic data and density functional theory (DFT) calculations at B3LYP/3-21G ∗∗ level. Th...
10 CitationsSource
#1P.A. ArunkumarH-Index: 2
#2Gl ViswanathaH-Index: 1
Last. Belliyappa (St. John's Medical College)H-Index: 2
view all 5 authors...
Objective To investigate the relationship between serum electrolyte changes and cisplatin induced nephrotoxicity.
23 CitationsSource