Hiromu Sakurai
Suzuka University of Medical Science
ChemistryAllixinInsulinBiochemistryDiabetes mellitus
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Publications 17
#1Yutaka YoshikawaH-Index: 28
#2Hiromu Sakurai (Suzuka University of Medical Science)H-Index: 12
Last. Eugenio Garribba (University of Sassari)H-Index: 36
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This study presents the first systematic investigation of the anti-diabetic properties of non-oxido VIV complexes. In particular, the insulin-mimetic activity of [VIV(taci)2]4+, [VIV(inoH−3)2]2−, [VIV(dhab)2], [VIV(hyphPh)2], [VIV(cat)3]2− and [VIV(pdbh)2] – where taci is 1,3,5-triamino-1,3,5-trideoxy-cis-inositol, ino is cis-inositol, H2dhab is 2,2′-dihydroxyazobenzene, H2hyphPh is 3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazole, H2cat is catechol and H2pdbh is pentan-2,4-dione benzoylhydrazone – wa...
49 CitationsSource
#1Tânia Moniz (University of Porto)H-Index: 8
#2M. João Amorim (University of Porto)H-Index: 5
Last. Maria Rangel (University of Porto)H-Index: 19
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Abstract Results from an investigation in an in vivo model of STZ-induced diabetic rats demonstrate that compound bis (1,2-dimethyl-3-hydroxy-4(1H)-pyridinonate)zinc(II), Zn(dmpp) 2 , significantly lowers the blood glucose levels of individuals, thus showing evidence of glucose lowering activity. The compound was selected from a set of eight zinc(II) complexes of 3-hydroxy-4-pyridinones with diverse lipophilicity that were prepared and characterized in our laboratory. Assessment of insulin-like ...
23 CitationsSource
#1Yutaka Yoshikawa (Kyoto Pharmaceutical University)H-Index: 28
#2Yusuke Adachi (Kyoto Pharmaceutical University)H-Index: 21
Last. Hiromu Sakurai (Suzuka University of Medical Science)H-Index: 12
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In recent years, the number of patients suffering from diseases, such as cancer, apoplexy, osteoporosis, hypertension, and type 2 diabetes mellitus is increasing worldwide. Type 2 diabetes, a lifestyle-related disease, is recognized as a serious disease. Various types of pharmaceutics for diabetes have been used. Since the relationship between diabetes and biometals such as vanadium, copper, and zinc ions has been recognized for many years, we have been developing the anti-diabetic metal complex...
16 CitationsSource
#1Mitsuru Hoshino (Osaka University of Pharmaceutical Sciences)H-Index: 4
#2Hiroyuki Yasui (Kyoto Pharmaceutical University)H-Index: 32
Last. Yoshikazu Fujita (Osaka University of Pharmaceutical Sciences)H-Index: 16
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Simultaneous and fractional determination of iron(II) and iron(III) was accomplished with o-hydroxyhydroquinonephthalein (QP) in the presence of poly (N-vinyl pyrrolidone). In the determination of total iron (iron(II)+iron(III)), Beer's law was obeyed in the range of 0.02-0.67 μg·ml−1, with an effective molar absorptivity (at 570 nm) and a relative standard deviation of 1.30×105·l·mol−1·cm−1 and 0.77% (n = 8), respectively. This method was about 10-15 times and more than the methods using 1,10-p...
3 CitationsSource
#1Yutaka Yoshikawa (Kyoto Pharmaceutical University)H-Index: 28
#2Akito Murayama (Kyoto Pharmaceutical University)H-Index: 1
Last. Hiroyuki Yasui (Kyoto Pharmaceutical University)H-Index: 32
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The number of worldwide patients suffering from diabetes mellitus (DM) is forecasted to increase over time. The development of compounds without severe side effects for type 2 DM is required not only to treat DM but also to improve the quality of life (QOL) of patients. In this paper, we have described the synthesis of novel first transition metal complexes with S2O2 coordination mode and discussed their anti-diabetic activities. Di(1-oxy-2-pyridinethiolato)Zn complex (Zn(opt)2) with Zn(S2O2) co...
15 CitationsSource
#1Hiromu Sakurai (Suzuka University of Medical Science)H-Index: 12
#2Akira Katoh (Seikei University)H-Index: 17
Last. Masakazu HattoriH-Index: 5
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Metabolic syndrome and the accompanied diabetes mellitus are both important diseases worldwide due to changes of lifestyle and eating habits. The number of patients with diabetes worldwide is estimated to increase to 300 million by 2025 from 150–220 million in 2010. There are two main types of diabetes. In type 1 diabetes, caused by destruction of pancreatic β-cells resulting in absolute deficiency of intrinsic insulin secretion, the patients require exogenous insulin injections several times a ...
35 CitationsSource
#1Sílvia Chaves (IST: Instituto Superior Técnico)H-Index: 16
#2Ratomir Jelić (IST: Instituto Superior Técnico)H-Index: 10
Last. M. Amélia Santos (IST: Instituto Superior Técnico)H-Index: 24
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The development of metal-containing pharmaceuticals as insulin-mimetics has been the object of recent worldwide research. We have examined a series of zinc(II) and molybdenum(VI) complexes with model O,S-donor ligands (thiomaltol and 1,2-dimethyl-3-hydroxypyridine-4-thione (DMHTP)) and the corresponding O,O-analogues (maltol and DMHP) for their insulin-mimetic activity. Aimed at getting structure-activity relationships, some physical-chemical properties were also studied, such as metal-complex f...
21 CitationsSource
#1Hiromu Sakurai (Suzuka University of Medical Science)H-Index: 12
This review introduces the development of metal-containing pharmaceutics (metallopharmaceutics) such as anticancer agents containing platinum (Pt) and ruthenium (Ru), and superoxide dismutase (SOD) mimetic, focusing on the recent topics on antidiabetic vanadium (V) and zinc (Zn) complexes as well as antioxidative copper (Cu) and Zn complexes. From the ancient ages, people used many types of inorganic compounds to treat physical disorders or diseases. Since the modern concept of chemotherapy was ...
16 CitationsSource
#1Yutaka Yoshikawa (Kyoto Pharmaceutical University)H-Index: 28
#2Ryoko Hirata (Kyoto Pharmaceutical University)H-Index: 2
Last. Hiromu Sakurai (Suzuka University of Medical Science)H-Index: 12
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We investigated the effects of divalent alkaline earth and first-row transition metal and zinc ions on α-glucosidase activityin vitro and in vivo. CuSO4 and ZnSO4 exhibited a high α-glucosidase inhibitory effect in vitro. The IC50 values of CuSO4 were 0.77 ± 0.01 (substrate; maltose) and 0.78 ± 0.01 (substrate; sucrose), and those of ZnSO4 were 5.49 ± 0.14 (substrate; maltose) and 4.70 ± 0.06 (substrate; sucrose) for yeast α-glucosidase. On the basis of Lineweaver–Burk plots, both CuSO4 and ZnSO...
10 CitationsSource
#1Yutaka Yoshikawa (Kyoto Pharmaceutical University)H-Index: 28
#2Ryoko Hirata (Kyoto Pharmaceutical University)H-Index: 2
Last. Hiromu Sakurai (Suzuka University of Medical Science)H-Index: 12
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We found alpha-glucosidase inhibitory (α-GI) effect of metal ions and their complexes which showed the high blood glucose lowering effect in diabetic model animals. The Cu(II) ion and its complexes showed strong α-GI activity greater than clinically used acarbose in in vitro studies. Furthermore, in in vivo experiments, α-GI action was newly discovered in normal ddy mice. These results suggested that one of action mechanisms of the anti-diabetic metal ions and complexes is related to the α-GI ef...
16 CitationsSource