Cardioprotection by resveratrol: a novel mechanism via autophagy involving the mTORC2 pathway
Abstract
On the basis of our previous reports that cardioprotection induced by ischaemic preconditioning induces autophagy and that resveratrol, a polyphenolic antioxidant present in grapes and red wine induces preconditioning-like effects, we sought to determine if resveratrol could induce autophagy.Resveratrol at lower doses (0.1 and 1 microM in H9c2 cardiac myoblast cells and 2.5 mg/kg/day in rats) induced cardiac autophagy shown by enhanced formation...
Paper Details
Title
Cardioprotection by resveratrol: a novel mechanism via autophagy involving the mTORC2 pathway
Published Date
Dec 3, 2009
Journal
Volume
86
Issue
1
Pages
103 - 112
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