Match!

Adipose Tissue, Inflammation, and Cardiovascular Disease

Published on May 13, 2005in Circulation Research15.862
· DOI :10.1161/01.RES.0000163635.62927.34
Anders H Berg A H30
Estimated H-index: 30
(Yeshiva University),
Philipp E. Scherer112
Estimated H-index: 112
Abstract
Mounting evidence highlights the role of adipose tissue in the development of a systemic inflammatory state that contributes to obesity-associated vasculopathy and cardiovascular risk. Circulating mediators of inflammation participate in the mechanisms of vascular insult and atheromatous change, and many of these inflammatory proteins are secreted directly from adipocytes and adipose tissue–derived macrophages. Several factors linking obesity with an increased cardiovascular risk have been identified. The adipocyte-specific secretory protein adiponectin is a particularly promising candidate in this context. Its levels are decreased in obesity. Adiponectin may mediate some of its demonstrated cardioprotective effects through its anti-inflammatory properties. In addition to decreased expression of beneficial adipokines, secretion of a host of inflammatory factors from visceral adipose tissue may contribute to the increased cardiovascular risk associated with obesity. The cardioprotective effects of many of ...
  • References (119)
  • Citations (1488)
📖 Papers frequently viewed together
3,893 Citations
3,965 Citations
200343.07Nature
2,421 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References119
Newest
#1Bohan Wang (University of Liverpool)H-Index: 12
#2John R. Jenkins (University of Liverpool)H-Index: 16
Last. Paul Trayhurn (University of Liverpool)H-Index: 58
view all 3 authors...
The expression profile of a series of adipokine genes linked to inflammation has been examined by quantitative PCR during the differentiation of human preadipocytes to adipocytes in primary culture, together with the integrated effects of TNF-α on the expression of these adipokines in the differentiated adipocytes. Expression of the genes encoding adiponectin, leptin, and haptoglobin was highly differentiation dependent, the mRNA being undetectable predifferentiation with the level peaking 9–15 ...
200 CitationsSource
#1KwangkonkohH-Index: 44
#2Michael J. QuonH-Index: 75
Last. Eak Kyun ShinH-Index: 32
view all 10 authors...
Background—Biological mechanisms underlying statin and angiotensin II type 1 receptor blocker therapies differ. Therefore, we compared vascular and metabolic responses to these therapies either alone or in combination in hypercholesterolemic, hypertensive patients. Methods and Results—This was a randomized, double-blind, placebo-controlled crossover trial with 3 treatment arms (each 2 months) and 2 washout periods (each 2 months). Forty-seven hypertensive, hypercholesterolemic patients were give...
253 CitationsSource
#1Anders H Berg A H (Yeshiva University)H-Index: 30
#2Ying Lin (Yeshiva University)H-Index: 11
Last. Philipp E. SchererH-Index: 112
view all 4 authors...
The adipocyte exerts an important role in energy homeostasis, both as depot for energy-rich triglycerides and as a source for metabolic hormones. Adipocytes also contribute to inflammation and the innate immune response. Although it can be physiologically beneficial to combine these two functions in a single cell type under some circumstances, the proinflammatory signals emanating from adipocytes in the obese state can have local and systemic effects that promote atherosclerosis and insulin resi...
124 CitationsSource
#1Mark Woodward (USYD: University of Sydney)H-Index: 115
#2G. D. O. Lowe (Glas.: University of Glasgow)H-Index: 8
Last. Stuart M. Cobbe (Glas.: University of Glasgow)H-Index: 46
view all 5 authors...
A randomized, double-blind multicenter trial-the Clopidogrel and Aspirin: Determination of the Effects on Thrombogenicity (CADET) trial-was carried out to compare the effects of clopidogrel vs. aspirin on thrombotic variables and C-reactive protein (CRP), over a 6-month period of treatment, in patients with an acute myocardial infarction within the previous 3-7 days, who were not scheduled for major surgery including coronary artery bypass grafting. Patients (n = 184) were randomly allocated to ...
61 CitationsSource
#1Carlos A. Labarrere (HealthPartners)H-Index: 23
#2Gary P. Zaloga (IU: Indiana University)H-Index: 30
There is compelling evidence that C-reactive protein is a sensitive marker for the development of cardiovascular disease in the general population. Recent studies suggest that C-reactive protein is not only a biomarker but also an active mediator in the pathogenesis of atherosclerosis. We review the evidence and suggest mechanisms by which C-reactive protein can damage arterial endothelium and promote the development of atherosclerotic lesions, including the effects of C-reactive protein on arte...
141 CitationsSource
#1Greeshma K. ShettyH-Index: 7
Last. Aristidis VevesH-Index: 57
view all 5 authors...
OBJECTIVE —Adiponectin and resistin, two recently discovered adipocyte-secreted hormones, may link obesity with insulin resistance and/or metabolic and cardiovascular risk factors. We performed a cross-sectional study to investigate the association of adiponectin and resistin with inflammatory markers, hyperlipidemia, and vascular reactivity and an interventional study to investigate whether atorvastatin mediates its beneficial effects by altering adiponectin or resistin levels. RESEARCH DESIGN ...
365 CitationsSource
#1Junji Kamon (UTokyo: University of Tokyo)H-Index: 19
#2Toshimasa Yamauchi (UTokyo: University of Tokyo)H-Index: 64
Last. Takashi Kadowaki (UTokyo: University of Tokyo)H-Index: 125
view all 11 authors...
Adiponectin is an anti-diabetic and anti-atherogenic hormone that is exclusively secreted from fat cells. Serum adiponectin levels are reduced in obese patients and obese model mice, despite increased adipose tissue mass. Elucidation of the mechanism(s) by which plasma adiponectin levels are decreased in obese and diabetic patients would provide insight into the cause of obesity-induced diabetes and the development of therapeutic advances. In the present study, the regulation of adiponectin secr...
69 CitationsSource
#1Ingrid Wernstedt (Sahlgrenska University Hospital)H-Index: 10
#2Anna L. Eriksson (Sahlgrenska University Hospital)H-Index: 14
Last. Jansson Jo (Sahlgrenska University Hospital)H-Index: 5
view all 10 authors...
OBJECTIVE: Human body fat mass is to a large extent genetically determined, but little is known about the susceptibility genes for common obesity. Interleukin-6 (IL-6) suppresses body fat mass in rodents, and IL-6 treatment increases energy expenditure in both rodents and humans. The -174 G/C single-nucleotide polymorphism (SNP) in the IL-6 gene promoter is common in many populations, and -174 C-containing promoters have been found to be weaker enhancers of transcription. Moreover, a SNP at posi...
80 CitationsSource
#1Qingwei Zhao (Kyushu University)H-Index: 14
#2Minako Ishibashi (Kyushu University)H-Index: 23
Last. Kensuke Egashira (Kyushu University)H-Index: 79
view all 6 authors...
Angiotensin II (Ang II) upregulates vascular endothelial growth factor (VEGF) and activates vascular inflammation. However, the decisive role of VEGF in Ang II–induced vascular inflammation and remodeling has not been addressed. Ang II infusion to wild-type mice increased local expression of VEGF and its receptors in cells of aortic wall and plasma VEGF, and caused aortic inflammation (monocyte infiltration) and remodeling (wall thickening and fibrosis). Hypoxia-inducible factor-1α colocalized w...
131 CitationsSource
#1Muredach P. Reilly (UPenn: University of Pennsylvania)H-Index: 92
#2Nayyar Iqbal (VA: United States Department of Veterans Affairs)H-Index: 22
Last. Stephen E. Kimmel (UPenn: University of Pennsylvania)H-Index: 66
view all 8 authors...
Leptin signaling may promote atherothrombosis and lead to cardiovascular disease. However, whether leptin is associated with human atherosclerosis, distinct from thrombosis, is unknown. We determined the association of plasma leptin levels with coronary artery calcification (CAC), a measure of coronary atherosclerosis, in a cross-sectional study of type 2 diabetes. Leptin levels were associated with CAC after adjusting for established risk factors [odds ratio (95% confidence interval) for 5 ng/m...
179 CitationsSource
Cited By1488
Newest
Source
#1Katarzyna Polonis (Mayo Clinic)H-Index: 2
#2Christiane Becari (Mayo Clinic)H-Index: 3
Last. Prachi Singh (Pennington Biomedical Research Center)H-Index: 16
view all 8 authors...
Obstructive sleep apnea (OSA) is a common sleep disorder associated with obesity. Emerging evidence suggest that OSA increases the risk of cardiovascular morbidity and mortality partly via accelerating the process of cellular aging. Thus, we sought to examine the effects of intermittent hypoxia (IH), a hallmark of OSA, on senescence in human white preadipocytes. We demonstrate that chronic IH is associated with an increased generation of mitochondrial reactive oxygen species along with increased...
Source
#1Julia Rogal (Fraunhofer Society)H-Index: 3
#2Carina Binder (Fraunhofer Society)H-Index: 1
Last. Peter Loskill (Fraunhofer Society)H-Index: 18
view all 8 authors...
Obesity and its numerous adverse health consequences have taken on global, pandemic proportions. White adipose tissue (WAT) – a key contributor in many metabolic diseases – contributes about one fourth of a healthy human’s body mass. Despite its significance, many WAT-related pathophysiogical mechanisms in humans are still not understood, largely due to the reliance on non-human animal models. In recent years, Organ-on-a-chip (OoC) platforms have developed into promising alternatives for animal ...
Source
#1Nabarun Chakraborty (WRAIR: Walter Reed Army Institute of Research)H-Index: 2
#2Aarti Gautam (WRAIR: Walter Reed Army Institute of Research)
Last. Rasha Hammamieh (WRAIR: Walter Reed Army Institute of Research)H-Index: 15
view all 11 authors...
Lethal total body irradiation (TBI) triggers multifactorial health issues in a potentially short time frame. Hence, early signatures of TBI would be of great clinical value. Our study aimed to interrogate microRNA (miRNA) and metabolites, two biomolecules available in blood serum, in order to comprehend the immediate impacts of TBI. Mice were exposed to a lethal dose (9.75 Gy) of Cobalt-60 gamma radiation and euthanized at four time points, namely, days 1, 3, 7 and 9 post-TBI. Serum miRNA librar...
Source
OBJECTIVE: This study aimed to determine the effects of physical exercise on the angio-adaptive response in adipose tissue following weight loss in a mouse model of diet-induced obesity. We hypothesized that physical exercise stimulates angiogenesis through the regulation of Vascular endothelial growth factor-A (VEGF-A) pro-/Thrombospondin-1 (TSP-1) anti-angiogenic signal under the control of the Murine double-minute 2/Forkhead box Os (Mdm2/FoxOs) axis, as reported in skeletal muscle. METHODS: W...
Source
#1Luoyun Fang (H.I., S.I.: University of Agriculture, Faisalabad)
#2Mingyue Li (H.I., S.I.: University of Agriculture, Faisalabad)
view all 7 authors...
This study was conducted to investigate the effect of grape seed procyanidins (GSP) on growth performance, digestive enzyme activity, antioxidant enzyme activity and mRNA expression in weanling piglets. A total of 96 piglets (Pietrain x Large White) with an average initial body weight (BW) of 8.4 +/- 1.7 kg were weaned at 28 days, and randomly divided into 4 groups. Four groups of animals were fed with a basic diet supplemented with various doses of GSP (0, 40, 70 and 100 mg/kg respectively) dur...
Source
#1Hyuk In Yang (Yonsei University)H-Index: 6
#2Wonhee Cho (Yonsei University)H-Index: 1
Last. John C. Spence (U of A: University of Alberta)H-Index: 40
view all 11 authors...
OBJECTIVE: To propose a new anthropometric index that can be employed to better predict percent body fat (PBF) among young adults and to compare with current anthropometric indices. DESIGN: Cross-sectional. SETTING: All measurements were taken in a controlled laboratory setting in Seoul (South Korea), between 1 December 2015 and 30 June 2016. PARTICIPANTS: Eighty-seven young adults (18-35 years) who underwent dual-energy x-ray absorptiometry (DXA) were used for analysis. Multiple regression anal...
Source
#1Denis Seyres (NIHR: National Institute for Health Research)
#2Alessandra Cabassi (University of Cambridge)H-Index: 1
Last. Oliver Slingsby (NIHR: National Institute for Health Research)
view all 34 authors...
Providing a molecular characterisation of cardiometabolic syndrome (CMS) could improve our understanding of its pathogenesis and pathophysiology, and provide a step toward the development of better treatments. To this end, we performed a deep phenotyping analysis of 185 blood donors, 10 obese, and 10 lipodystrophy patients. We analysed transcriptomes and epigenomes of monocytes, neutrophils, macrophages and platelets. Additionally, plasma metabolites including lipids and biochemistry measurement...
Source
Abstract Adipocyte account for the largest component in breast tissue. Dysfunctional adipocyte metabolism, such as metaflammation in metabolically abnormal obese patients, will cause hyperplasia and hypertrophy of its constituent adipocytes. Inflamed adipose tissue is one of the biggest risk factors causing breast cancer. Factors linking adipocyte metabolism to breast cancer include dysfunctional secretion of proinflammatory mediators, proangiogenic factors and estrogens. The accumulation of tum...
Source
#1Mohamed Abdalla Salman (Cairo University)H-Index: 1
#2Mohamed Ahmed el-Ghobary (Cairo University)H-Index: 1
Last. Ahmed Salman (Cairo University)H-Index: 2
view all 15 authors...
Aim Published reports showed conflicting results regarding the sustained alterations in leptin, chemerin, and ghrelin concenratios after metabolic surgery. Therefore, we performed the present work to contrast the alterations in leptin, chemerin, and ghrelin levels one year after Roux-en-Y gastric bypass (RYGB) versus laparoscopic sleeve gastrectomy (LSG).
Source