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Adipose Tissue, Inflammation, and Cardiovascular Disease

Published on May 13, 2005in Circulation Research15.86
· DOI :10.1161/01.RES.0000163635.62927.34
Anders H Berg A H31
Estimated H-index: 31
(Yeshiva University),
Philipp E. Scherer111
Estimated H-index: 111
Cite
Abstract
Mounting evidence highlights the role of adipose tissue in the development of a systemic inflammatory state that contributes to obesity-associated vasculopathy and cardiovascular risk. Circulating mediators of inflammation participate in the mechanisms of vascular insult and atheromatous change, and many of these inflammatory proteins are secreted directly from adipocytes and adipose tissue–derived macrophages. Several factors linking obesity with an increased cardiovascular risk have been identified. The adipocyte-specific secretory protein adiponectin is a particularly promising candidate in this context. Its levels are decreased in obesity. Adiponectin may mediate some of its demonstrated cardioprotective effects through its anti-inflammatory properties. In addition to decreased expression of beneficial adipokines, secretion of a host of inflammatory factors from visceral adipose tissue may contribute to the increased cardiovascular risk associated with obesity. The cardioprotective effects of many of ...
  • References (119)
  • Citations (1452)
Cite
References119
Newest
Bohan Wang11
Estimated H-index: 11
(University of Liverpool),
John R. Jenkins16
Estimated H-index: 16
(University of Liverpool),
Paul Trayhurn57
Estimated H-index: 57
(University of Liverpool)
The expression profile of a series of adipokine genes linked to inflammation has been examined by quantitative PCR during the differentiation of human preadipocytes to adipocytes in primary culture, together with the integrated effects of TNF-α on the expression of these adipokines in the differentiated adipocytes. Expression of the genes encoding adiponectin, leptin, and haptoglobin was highly differentiation dependent, the mRNA being undetectable predifferentiation with the level peaking 9–15 ...
Published on Dec 14, 2004in Circulation23.05
Kwangkonkoh42
Estimated H-index: 42
,
Michael J. Quon74
Estimated H-index: 74
+ 7 AuthorsEak Kyun Shin32
Estimated H-index: 32
Background—Biological mechanisms underlying statin and angiotensin II type 1 receptor blocker therapies differ. Therefore, we compared vascular and metabolic responses to these therapies either alone or in combination in hypercholesterolemic, hypertensive patients. Methods and Results—This was a randomized, double-blind, placebo-controlled crossover trial with 3 treatment arms (each 2 months) and 2 washout periods (each 2 months). Forty-seven hypertensive, hypercholesterolemic patients were give...
Anders H Berg A H31
Estimated H-index: 31
(Yeshiva University),
Ying Lin12
Estimated H-index: 12
(Yeshiva University)
+ 1 AuthorsPhilipp E. Scherer111
Estimated H-index: 111
The adipocyte exerts an important role in energy homeostasis, both as depot for energy-rich triglycerides and as a source for metabolic hormones. Adipocytes also contribute to inflammation and the innate immune response. Although it can be physiologically beneficial to combine these two functions in a single cell type under some circumstances, the proinflammatory signals emanating from adipocytes in the obese state can have local and systemic effects that promote atherosclerosis and insulin resi...
Published on Nov 1, 2004in Journal of Thrombosis and Haemostasis4.66
Mark Woodward110
Estimated H-index: 110
(USYD: University of Sydney),
G. D. O. Lowe15
Estimated H-index: 15
(Glas.: University of Glasgow)
+ 2 AuthorsStuart M. Cobbe46
Estimated H-index: 46
(Glas.: University of Glasgow)
A randomized, double-blind multicenter trial-the Clopidogrel and Aspirin: Determination of the Effects on Thrombogenicity (CADET) trial-was carried out to compare the effects of clopidogrel vs. aspirin on thrombotic variables and C-reactive protein (CRP), over a 6-month period of treatment, in patients with an acute myocardial infarction within the previous 3-7 days, who were not scheduled for major surgery including coronary artery bypass grafting. Patients (n = 184) were randomly allocated to ...
Published on Nov 1, 2004in International Journal of Obesity4.51
T Skurk1
Estimated H-index: 1
,
Hans Hauner53
Estimated H-index: 53
Obesity and impaired fibrinolysis: role of adipose production of plasminogen activator inhibitor-1
Published on Oct 1, 2004in Diabetes Care15.27
Greeshma K. Shetty5
Estimated H-index: 5
,
Panayiotis A. Economides9
Estimated H-index: 9
+ 2 AuthorsAristidis Veves57
Estimated H-index: 57
OBJECTIVE —Adiponectin and resistin, two recently discovered adipocyte-secreted hormones, may link obesity with insulin resistance and/or metabolic and cardiovascular risk factors. We performed a cross-sectional study to investigate the association of adiponectin and resistin with inflammatory markers, hyperlipidemia, and vascular reactivity and an interventional study to investigate whether atorvastatin mediates its beneficial effects by altering adiponectin or resistin levels. RESEARCH DESIGN ...
Published on Oct 1, 2004in Biochemical and Biophysical Research Communications2.71
Junji Kamon19
Estimated H-index: 19
(UTokyo: University of Tokyo),
Toshimasa Yamauchi62
Estimated H-index: 62
(UTokyo: University of Tokyo)
+ 8 AuthorsKazuyuki Tobe66
Estimated H-index: 66
(UTokyo: University of Tokyo)
Abstract Adiponectin is an anti-diabetic and anti-atherogenic hormone that is exclusively secreted from fat cells. Serum adiponectin levels are reduced in obese patients and obese model mice, despite increased adipose tissue mass. Elucidation of the mechanism(s) by which plasma adiponectin levels are decreased in obese and diabetic patients would provide insight into the cause of obesity-induced diabetes and the development of therapeutic advances. In the present study, the regulation of adipone...
Published on Oct 1, 2004in The American Journal of Medicine4.76
Carlos A. Labarrere23
Estimated H-index: 23
(HealthPartners),
Gary P. Zaloga28
Estimated H-index: 28
(IU: Indiana University)
There is compelling evidence that C-reactive protein is a sensitive marker for the development of cardiovascular disease in the general population. Recent studies suggest that C-reactive protein is not only a biomarker but also an active mediator in the pathogenesis of atherosclerosis. We review the evidence and suggest mechanisms by which C-reactive protein can damage arterial endothelium and promote the development of atherosclerotic lesions, including the effects of C-reactive protein on arte...
Published on Oct 1, 2004in International Journal of Obesity4.51
Ingrid Wernstedt10
Estimated H-index: 10
(Sahlgrenska University Hospital),
Anna L. Eriksson13
Estimated H-index: 13
(Sahlgrenska University Hospital)
+ 7 AuthorsJansson Jo4
Estimated H-index: 4
(Sahlgrenska University Hospital)
OBJECTIVE: Human body fat mass is to a large extent genetically determined, but little is known about the susceptibility genes for common obesity. Interleukin-6 (IL-6) suppresses body fat mass in rodents, and IL-6 treatment increases energy expenditure in both rodents and humans. The -174 G/C single-nucleotide polymorphism (SNP) in the IL-6 gene promoter is common in many populations, and -174 C-containing promoters have been found to be weaker enhancers of transcription. Moreover, a SNP at posi...
Published on Sep 1, 2004in Hypertension7.02
Qingwei Zhao14
Estimated H-index: 14
(Kyushu University),
Minako Ishibashi22
Estimated H-index: 22
(Kyushu University)
+ 3 AuthorsKensuke Egashira78
Estimated H-index: 78
(Kyushu University)
Angiotensin II (Ang II) upregulates vascular endothelial growth factor (VEGF) and activates vascular inflammation. However, the decisive role of VEGF in Ang II–induced vascular inflammation and remodeling has not been addressed. Ang II infusion to wild-type mice increased local expression of VEGF and its receptors in cells of aortic wall and plasma VEGF, and caused aortic inflammation (monocyte infiltration) and remodeling (wall thickening and fibrosis). Hypoxia-inducible factor-1α colocalized w...
Cited By1452
Newest
Published on Dec 1, 2019in Cell Communication and Signaling
Hanchao Gao1
Estimated H-index: 1
(SZU: Shenzhen University),
Mengtao Cao (SZU: Shenzhen University)+ 8 AuthorsShaodong Luan1
Estimated H-index: 1
Background The major limitation of organ transplantation is the shortage of available organs. Xenotransplantation is considered to be an effective way to resolve the problem. Immune rejection is a major hurdle for the successful survival of pig xenografts in primate recipients. Cytokines play important roles in inflammation and many diseases including allotransplantation, however, their roles in xenotransplantation have been less well investigated.
Published on Jul 17, 2019in Human & Experimental Toxicology2.17
Ahu Soyocak1
Estimated H-index: 1
(Istanbul Aydın University),
Hulyam Kurt7
Estimated H-index: 7
(Eskişehir Osmangazi University)
+ 7 AuthorsHasan Veysi Gunes12
Estimated H-index: 12
(Eskişehir Osmangazi University)
Published on Oct 1, 2019in Diabetology international
Miki Okada-Iwabu16
Estimated H-index: 16
(UTokyo: University of Tokyo),
Masato Iwabu16
Estimated H-index: 16
(UTokyo: University of Tokyo)
+ 1 AuthorsTakashi Kadowaki121
Estimated H-index: 121
(UTokyo: University of Tokyo)
It is well recognized that the decrease of adiponectin associated with high-fat diet and lack of exercise accounts for the onset of insulin resistance, type 2 diabetes, the metabolic syndrome, and cardiovascular disease. Our research efforts have led to the identification of adiponectin receptors, AdipoR1 and AdipoR2, with the former shown to activate AMP kinase in the liver and the latter shown to activate peroxisome proliferator-activated receptor-α signaling thereby increasing fatty acid oxid...
Published on Sep 26, 2019in Transboundary and Emerging Diseases3.55
Lorena Franco-Martínez3
Estimated H-index: 3
(University of Murcia),
Margarita Villar28
Estimated H-index: 28
(CSIC: Spanish National Research Council)
+ 9 AuthorsJosé de la Fuente59
Estimated H-index: 59
(OSU: Oklahoma State University–Stillwater)
Published on 2019in Current Medical Research and Opinion2.35
Addolorata Corrado17
Estimated H-index: 17
(University of Foggia),
R. Colia3
Estimated H-index: 3
(University of Foggia)
+ 2 AuthorsFrancesco Paolo Cantatore31
Estimated H-index: 31
(University of Foggia)
AbstractBackground. Rheumatoid arthritis (RA) is a chronic inflammatory joint disease characterized by an alteredglucose and lipid metabolism. Tumor necrosis factor alpha (TNF-α is involved in the ...
Published on Sep 9, 2019in PLOS ONE2.78
Seung Joo Lee8
Estimated H-index: 8
,
Jeong Suk Kang4
Estimated H-index: 4
+ 4 AuthorsEun Y. Lee41
Estimated H-index: 41
Published on Sep 3, 2019in European Heart Journal23.24
E. Oikonomou18
Estimated H-index: 18
(John Radcliffe Hospital),
Michelle C Williams13
Estimated H-index: 13
(BHF: British Heart Foundation)
+ 26 AuthorsLampson M. Fan12
Estimated H-index: 12
(John Radcliffe Hospital)
Published on May 6, 2019in The Journal of Clinical Endocrinology and Metabolism5.61
Oscar Bergens1
Estimated H-index: 1
(RMIT: RMIT University),
Andreas Nilsson14
Estimated H-index: 14
(RMIT: RMIT University),
Fawzi Kadi38
Estimated H-index: 38
(RMIT: RMIT University)
View next paperThe fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity.