Original paper
Crystal structures of a multidrug transporter reveal a functionally rotating mechanism
Abstract
AcrB is a principal multidrug efflux transporter in Escherichia coli that cooperates with an outer-membrane channel, TolC, and a membrane-fusion protein, AcrA. Here we describe crystal structures of AcrB with and without substrates. The AcrB-drug complex consists of three protomers, each of which has a different conformation corresponding to one of the three functional states of the transport cycle. Bound substrate was found in the periplasmic...
Paper Details
Title
Crystal structures of a multidrug transporter reveal a functionally rotating mechanism
Published Date
Aug 16, 2006
Journal
Volume
443
Issue
7108
Pages
173 - 179
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Notes
History