Obesity as Compared With Physical Activity in Predicting Risk of Coronary Heart Disease in Women

Published on Jan 31, 2006in Circulation23.05
· DOI :10.1161/CIRCULATIONAHA.105.574087
Tricia Li34
Estimated H-index: 34
Jamal S. Rana17
Estimated H-index: 17
+ 5 AuthorsFrank B. Hu202
Estimated H-index: 202
Background— The comparative importance of physical inactivity and obesity as predictors of coronary heart disease (CHD) risk remains unsettled. Methods and Results— We followed 88 393 women, 34 to 59 years of age, in the Nurses’ Health Study from 1980 to 2000. These participants did not have cardiovascular disease and cancer at baseline. We documented 2358 incident major CHD events (including nonfatal myocardial infarction and fatal CHD) during 20 years of follow-up, including 889 cases of fatal CHD and 1469 cases of nonfatal myocardial infarction. In a multivariate model adjusting for cardiovascular risk factors, overweight and obesity were significantly associated with increased risk of CHD, whereas increasing levels of physical activity were associated with a graded reduction in CHD risk (P<0.001). In joint analyses of body mass index (BMI) and physical activity in women who had a healthy weight (BMI, 18.5 to 24.9 kg/m2) and were physically active (exercise ≥3.5 h/wk) as the reference group, the relati...
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