Aerobic training as an adjunctive therapy to enzyme replacement in Pompe disease

Aerobic exercise may be used in conjunction with enzyme replacement therapy (ERT) to attenuate cardiovascular deconditioning, skeletal muscle wasting, and loss of motor function in Pompe disease (glycogen storage disease type II; GSDII), but the effects on lysosomal glycogen content and macroautophagy have not been defined to date. The main objectives of this study were to determine if acute aerobic exercise enhances 24-h uptake of recombinant...