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Imtiaz A. Samjoo
McMaster University
16Publications
10H-index
435Citations
Publications 16
Newest
Published on Dec 1, 2015in Skeletal Muscle 4.00
Adeel Safdar25
Estimated H-index: 25
(McMaster University),
Konstantin Khrapko4
Estimated H-index: 4
(NU: Northeastern University)
+ 16 AuthorsDaniel I. Ogborn10
Estimated H-index: 10
(McMaster University)
Background Human genetic disorders and transgenic mouse models have shown that mitochondrial DNA (mtDNA) mutations and telomere dysfunction instigate the aging process. Epidemiologically, exercise is associated with greater life expectancy and reduced risk of chronic diseases. While the beneficial effects of exercise are well established, the molecular mechanisms instigating these observations remain unclear.
Published on Nov 1, 2015in Scientific Reports 4.01
M. Constantine Samaan9
Estimated H-index: 9
,
Sonia S. Anand74
Estimated H-index: 74
+ 4 AuthorsMark A. Tarnopolsky93
Estimated H-index: 93
South Asians (SA) are at higher risk of cardiometabolic disorders than Europeans (EU), yet the potential determinants of this risk are poorly understood. We tested the hypotheses that 1) South Asians (SA) have greater muscle inflammation compared to Europeans (EU) at similar fat mass 2) differential regional adiposity in SA compared to EU is associated with enhanced muscle inflammation in SA. This cross-sectional study was conducted at a tertiary academic center in Hamilton, Ontario, Canada. The...
Published on Aug 1, 2015in Scientific Reports 4.01
M. Constantine Samaan9
Estimated H-index: 9
,
Sonia S. Anand74
Estimated H-index: 74
+ 2 AuthorsMark A. Tarnopolsky93
Estimated H-index: 93
Women have higher adiposity but maintain insulin sensitivity when compared to men. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibits insulin signaling, but it is not known if PTEN regulate insulin resistance in a sex-specific manner. In this cross-sectional study, muscle biopsies from participants in the Molecular Study of Health and Risk in Ethnic Groups (Mol-SHARE) were used to test for sex differences in PTEN expression. Quantitative real-time PCR was performed to determ...
Published on Dec 1, 2013in The Journal of Clinical Endocrinology and Metabolism 5.61
Michaela C. Devries21
Estimated H-index: 21
(McMaster University),
Imtiaz A. Samjoo10
Estimated H-index: 10
(McMaster University)
+ 5 AuthorsMark A. Tarnopolsky93
Estimated H-index: 93
(McMaster University)
Context: The accumulation of intramyocellular lipids (IMCLs) and mitochondrial dysfunction in skeletal muscle have been associated with insulin resistance in obesity. Endurance training (ET) increases mitochondrial content/activity and IMCL content in young, active men and women. We have previously shown that ET alters the size, number, and physical juxtaposition of IMCLs and mitochondria. Objective: The purpose of this study was to determine the effects of obesity and ET on mitochondrial functi...
Published on Sep 1, 2013in Nutrition & Diabetes 3.10
Imtiaz A. Samjoo10
Estimated H-index: 10
,
Adeel Safdar25
Estimated H-index: 25
+ 2 AuthorsMark A. Tarnopolsky93
Estimated H-index: 93
BACKGROUND: Obesity is associated with low-grade systemic inflammation, in part because of secretion of proinflammatory cytokines, resulting into peripheral insulin resistance (IR). Increased oxidative stress is proposed to link adiposity and chronic inflammation. The effects of endurance exercise in modulating these outcomes in insulin-resistant obese adults remain unclear. We investigated the effect of endurance exercise on markers of oxidative damage (4-hydroxy-2-nonenal (4-HNE), protein carb...
Published on Jun 12, 2013in PLOS ONE 2.78
Imtiaz A. Samjoo10
Estimated H-index: 10
(McMaster University),
Adeel Safdar25
Estimated H-index: 25
(Harvard University)
+ 7 AuthorsMark A. Tarnopolsky93
Estimated H-index: 93
(McMaster University)
Lower skeletal muscle mitochondrial oxidative phosphorylation capacity (OXPHOS) and intramyocellular lipid (IMCL) accumulation have been implicated in the etiology of insulin resistance (IR) in obesity. The purpose of this study was to examine the impact of endurance exercise on biochemical and morphological measures of IMCL and mitochondrial content, and their relationship to IR in obese individuals. We examined mitochondrial content (subunit protein abundance and maximal activity of electron t...
Published on Nov 1, 2012in Molecular Genetics and Metabolism 3.61
Mats I. Nilsson12
Estimated H-index: 12
(McMaster University),
Imtiaz A. Samjoo10
Estimated H-index: 10
(McMaster University)
+ 11 AuthorsMohammad U. Ansari1
Estimated H-index: 1
(McMaster University)
Abstract Background Aerobic exercise may be used in conjunction with enzyme replacement therapy (ERT) to attenuate cardiovascular deconditioning, skeletal muscle wasting, and loss of motor function in Pompe disease (glycogen storage disease type II; GSDII), but the effects on lysosomal glycogen content and macroautophagy have not been defined to date. Purpose The main objectives of this study were to determine if acute aerobic exercise enhances 24-h uptake of recombinant human enzyme (rhGAA; Myo...
Published on Aug 1, 2012in Applied Physiology, Nutrition, and Metabolism 3.46
Sandra J. Peters18
Estimated H-index: 18
,
Imtiaz A. Samjoo10
Estimated H-index: 10
+ 3 AuthorsMark A. Tarnopolsky93
Estimated H-index: 93
Proteins that coat the lipid droplets (also known as PAT proteins or perilipin (PLIN) family proteins) have diverse functions that are not well elucidated in many tissues. In skeletal muscle, there is even less known about the functions or characteristics of these proteins or how they might change in response to perturbations that alter both intramyocellular lipid (IMCL) content and fat utilization and oxidation. Therefore, the purpose of this study was to examine the human muscle content and ge...
Published on Mar 19, 2012in PLOS ONE 2.78
Emily K. Hayes2
Estimated H-index: 2
(McMaster University),
Anna Lechowicz1
Estimated H-index: 1
(McMaster University)
+ 8 AuthorsAlison C. Holloway34
Estimated H-index: 34
(McMaster University)
Maternal obesity results in a number of obstetrical and fetal complications with both immediate and long-term consequences. The increased prevalence of obesity has resulted in increasing numbers of women of reproductive age in this high-risk group. Since many of these obese women have been subjected to hypercaloric diets from early childhood we have developed a rodent model of life-long maternal obesity to more clearly understand the mechanisms that contribute to adverse pregnancy outcomes in ob...
Published on Apr 1, 2010in The FASEB Journal 5.39
Imtiaz A. Samjoo10
Estimated H-index: 10
(McMaster University),
Adeel Safdar25
Estimated H-index: 25
(McMaster University)
+ 4 AuthorsMark A. Tarnopolsky93
Estimated H-index: 93
(McMaster University)
The causal role of mitochondrial dysfunction and mtDNA mutagenesis in the etiology of obesity and type 2 diabetes remains equivocal. We revisited this controversy by measuring mtDNA copy number, protein content of mitochondrial respiratory chain subunits (COX –II and –IV) and mitochondrial COX activity in the vastus lateralis of lean and obese men (N=9/group). Obese men had significantly higher total body weight (44%) and fat mass (140%) compared to the lean controls (P<0.01). Interestingly, the...
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