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Imtiaz A. Samjoo
McMaster University
16Publications
10H-index
475Citations
Publications 16
Newest
#1Adeel Safdar (McMaster University)H-Index: 27
#2Konstantin Khrapko (NU: Northeastern University)H-Index: 4
Last.Mark A. Tarnopolsky (McMaster University)H-Index: 96
view all 19 authors...
Background Human genetic disorders and transgenic mouse models have shown that mitochondrial DNA (mtDNA) mutations and telomere dysfunction instigate the aging process. Epidemiologically, exercise is associated with greater life expectancy and reduced risk of chronic diseases. While the beneficial effects of exercise are well established, the molecular mechanisms instigating these observations remain unclear.
39 CitationsSource
#2Sonia S. AnandH-Index: 76
Last.Mark A. TarnopolskyH-Index: 96
view all 7 authors...
South Asians (SA) are at higher risk of cardiometabolic disorders than Europeans (EU), yet the potential determinants of this risk are poorly understood. We tested the hypotheses that 1) South Asians (SA) have greater muscle inflammation compared to Europeans (EU) at similar fat mass 2) differential regional adiposity in SA compared to EU is associated with enhanced muscle inflammation in SA. This cross-sectional study was conducted at a tertiary academic center in Hamilton, Ontario, Canada. The...
2 CitationsSource
#2Sonia S. AnandH-Index: 76
Last.Mark A. TarnopolskyH-Index: 96
view all 5 authors...
Women have higher adiposity but maintain insulin sensitivity when compared to men. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibits insulin signaling, but it is not known if PTEN regulate insulin resistance in a sex-specific manner. In this cross-sectional study, muscle biopsies from participants in the Molecular Study of Health and Risk in Ethnic Groups (Mol-SHARE) were used to test for sex differences in PTEN expression. Quantitative real-time PCR was performed to determ...
4 CitationsSource
#1Michaela C. Devries (McMaster University)H-Index: 22
#2Imtiaz A. Samjoo (McMaster University)H-Index: 10
Last.Mark A. Tarnopolsky (McMaster University)H-Index: 96
view all 8 authors...
Context: The accumulation of intramyocellular lipids (IMCLs) and mitochondrial dysfunction in skeletal muscle have been associated with insulin resistance in obesity. Endurance training (ET) increases mitochondrial content/activity and IMCL content in young, active men and women. We have previously shown that ET alters the size, number, and physical juxtaposition of IMCLs and mitochondria. Objective: The purpose of this study was to determine the effects of obesity and ET on mitochondrial functi...
33 CitationsSource
#1Imtiaz A. Samjoo (McMaster University)H-Index: 10
#2Adeel Safdar (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 27
Last.Mark A. Tarnopolsky (McMaster University)H-Index: 96
view all 5 authors...
BACKGROUND: Obesity is associated with low-grade systemic inflammation, in part because of secretion of proinflammatory cytokines, resulting into peripheral insulin resistance (IR). Increased oxidative stress is proposed to link adiposity and chronic inflammation. The effects of endurance exercise in modulating these outcomes in insulin-resistant obese adults remain unclear. We investigated the effect of endurance exercise on markers of oxidative damage (4-hydroxy-2-nonenal (4-HNE), protein carb...
52 CitationsSource
#1Imtiaz A. Samjoo (McMaster University)H-Index: 10
#2Adeel Safdar (Harvard University)H-Index: 27
Last.Mark A. Tarnopolsky (McMaster University)H-Index: 96
view all 10 authors...
Lower skeletal muscle mitochondrial oxidative phosphorylation capacity (OXPHOS) and intramyocellular lipid (IMCL) accumulation have been implicated in the etiology of insulin resistance (IR) in obesity. The purpose of this study was to examine the impact of endurance exercise on biochemical and morphological measures of IMCL and mitochondrial content, and their relationship to IR in obese individuals. We examined mitochondrial content (subunit protein abundance and maximal activity of electron t...
20 CitationsSource
#1Mats I. Nilsson (McMaster University)H-Index: 13
#2Imtiaz A. Samjoo (McMaster University)H-Index: 10
Last.Mark A. Tarnopolsky (McMaster University)H-Index: 96
view all 14 authors...
Abstract Background Aerobic exercise may be used in conjunction with enzyme replacement therapy (ERT) to attenuate cardiovascular deconditioning, skeletal muscle wasting, and loss of motor function in Pompe disease (glycogen storage disease type II; GSDII), but the effects on lysosomal glycogen content and macroautophagy have not been defined to date. Purpose The main objectives of this study were to determine if acute aerobic exercise enhances 24-h uptake of recombinant human enzyme (rhGAA; Myo...
17 CitationsSource
#1Sandra J. Peters (Brock University)H-Index: 19
#2Imtiaz A. Samjoo (McMaster University)H-Index: 10
Last.Mark A. Tarnopolsky (McMaster University)H-Index: 96
view all 6 authors...
Proteins that coat the lipid droplets (also known as PAT proteins or perilipin (PLIN) family proteins) have diverse functions that are not well elucidated in many tissues. In skeletal muscle, there is even less known about the functions or characteristics of these proteins or how they might change in response to perturbations that alter both intramyocellular lipid (IMCL) content and fat utilization and oxidation. Therefore, the purpose of this study was to examine the human muscle content and ge...
47 CitationsSource
#1Emily K. Hayes (McMaster University)H-Index: 2
#2Anna Lechowicz (McMaster University)H-Index: 1
Last.Sandeep Raha (McMaster University)H-Index: 25
view all 11 authors...
Maternal obesity results in a number of obstetrical and fetal complications with both immediate and long-term consequences. The increased prevalence of obesity has resulted in increasing numbers of women of reproductive age in this high-risk group. Since many of these obese women have been subjected to hypercaloric diets from early childhood we have developed a rodent model of life-long maternal obesity to more clearly understand the mechanisms that contribute to adverse pregnancy outcomes in ob...
76 CitationsSource
#1Imtiaz A. Samjoo (McMaster University)H-Index: 10
#2Adeel Safdar (McMaster University)H-Index: 27
Last.Mark A. Tarnopolsky (McMaster University)H-Index: 96
view all 7 authors...
The causal role of mitochondrial dysfunction and mtDNA mutagenesis in the etiology of obesity and type 2 diabetes remains equivocal. We revisited this controversy by measuring mtDNA copy number, pr...
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