Epistasis and quantitative traits: using model organisms to study gene–gene interactions
Abstract
The role of epistasis in the genetic architecture of quantitative traits is controversial, despite the biological plausibility that nonlinear molecular interactions underpin the genotype-phenotype map. This controversy arises because most genetic variation for quantitative traits is additive. However, additive variance is consistent with pervasive epistasis. In this Review, I discuss experimental designs to detect the contribution of epistasis...
Paper Details
Title
Epistasis and quantitative traits: using model organisms to study gene–gene interactions
Published Date
Dec 3, 2013
Journal
Volume
15
Issue
1
Pages
22 - 33
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