Neuronal activity regulates the regional vulnerability to amyloid-β deposition

Using a mouse model of Alzheimer's disease and in vivo microdialysis, this study shows that neuronal activity drives the level of interstitial fluid amyloid-β and subsequent amyloid-β plaque deposition. Amyloid-β (Aβ) plaque deposition in specific brain regions is a pathological hallmark of Alzheimer's disease. However, the mechanism underlying the regional vulnerability to Aβ deposition in Alzheimer's disease is unknown. Herein, we provide...