Genome Engineering with Targetable Nucleases
Abstract
Current technology enables the production of highly specific genome modifications with excellent efficiency and specificity. Key to this capability are targetable DNA cleavage reagents and cellular DNA repair pathways. The break made by these reagents can produce localized sequence changes through inaccurate nonhomologous end joining (NHEJ), often leading to gene inactivation. Alternatively, user-provided DNA can be used as a template for repair...
Paper Details
Title
Genome Engineering with Targetable Nucleases
Published Date
Jun 2, 2014
Volume
83
Issue
1
Pages
409 - 439
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