Pleiotropic effects of methionine adenosyltransferases deregulation as determinants of liver cancer progression and prognosis
Abstract
Downregulation of liver-specific MAT1A gene, encoding S-adenosylmethionine (SAM) synthesizing isozymes MATI/III, and upregulation of widely expressed MAT2A, encoding MATII isozyme, known as MAT1A:MAT2A switch, occurs in hepatocellular carcinoma (HCC). Being inhibited by its reaction product, MATII isoform upregulation cannot compensate for MATI/III decrease. Therefore, MAT1A:MAT2A switch contributes to decrease in SAM level in rodent and human...
Paper Details
Title
Pleiotropic effects of methionine adenosyltransferases deregulation as determinants of liver cancer progression and prognosis
Published Date
Oct 1, 2013
Journal
Volume
59
Issue
4
Pages
830 - 841
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