Original paper
Extensive Loss of Heterozygosity Is Suppressed during Homologous Repair of Chromosomal Breaks
Abstract
Loss of heterozygosity (LOH) is a common genetic alteration in tumors and often extends several megabases to encompass multiple genetic loci or even whole chromosome arms. Based on marker and karyotype analysis of tumor samples, a significant fraction of LOH events appears to arise from mitotic recombination between homologous chromosomes, reminiscent of recombination during meiosis. As DNA double-strand breaks (DSBs) initiate meiotic...
Paper Details
Title
Extensive Loss of Heterozygosity Is Suppressed during Homologous Repair of Chromosomal Breaks
Published Date
Jan 1, 2003
Volume
23
Issue
2
Pages
733 - 743
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Notes
History