Cbx4 Governs HIF-1α to Potentiate Angiogenesis of Hepatocellular Carcinoma by Its SUMO E3 Ligase Activity

Published on Jan 1, 2014in Cancer Cell23.92
· DOI :10.1016/j.ccr.2013.12.008
Jie Li3
Estimated H-index: 3
(SJTU: Shanghai Jiao Tong University),
Ying Xu7
Estimated H-index: 7
(CAS: Chinese Academy of Sciences)
+ 10 AuthorsGuo-Qiang Chen46
Estimated H-index: 46
(CAS: Chinese Academy of Sciences)
Summary Cbx4 is a polycomb group protein that is also a SUMO E3 ligase, but its potential roles in tumorigenesis remain to be explored. Here, we report that Cbx4, but not other members of the Cbx family, enhances hypoxia-induced vascular endothelial growth factor (VEGF) expression and angiogenesis in hepatocellular carcinoma (HCC) cells through enhancing HIF-1α sumoylations at K391 and K477 in its two SUMO-interacting motifs-dependent mechanisms and increasing transcriptional activity of HIF-1. The Cbx4 expression is significantly correlated with VEGF expression, angiogenesis, and the overall survival of HCC patients and also in subcutaneously and orthotopically transplanted mice HCC models. Collectively, our findings demonstrate that Cbx4 plays a critical role in tumor angiogenesis by governing HIF-1α protein.
  • References (52)
  • Citations (62)
#1Hui Yang (Fudan University)H-Index: 8
#2Yue Xiong (Fudan University)H-Index: 75
Last.Kun-Liang Guan (Fudan University)H-Index: 122
view all 3 authors...
#1Hira Lal Goel (SC: University of Southern California)H-Index: 21
#2Cheng Chang (SC: University of Southern California)H-Index: 9
Last.Ilsa M. Coleman (SC: University of Southern California)H-Index: 1
view all 15 authors...
#1Xue Zhao (Peking Union Medical College)H-Index: 3
#2Zhen Yang (Fudan University)H-Index: 11
Last.Ruoyu Miao (CAS: Chinese Academy of Sciences)H-Index: 12
view all 11 authors...
#1Lei Zhang (HUM: Hubei University of Medicine)H-Index: 12
#2Jia-Ning Wang (HUM: Hubei University of Medicine)H-Index: 14
Last.Lin Tian (HUM: Hubei University of Medicine)H-Index: 1
view all 14 authors...
Cited By62
#1Chao Tan (GLMU: Guilin Medical University)H-Index: 2
#2Chunhua Bei (GLMU: Guilin Medical University)H-Index: 4
Last.Shengkui Tan (GLMU: Guilin Medical University)H-Index: 4
view all 6 authors...
#1Yanru Fan (CQMU: Chongqing Medical University)H-Index: 3
#2Liping Ou (CQMU: Chongqing Medical University)H-Index: 4
Last.Lingfang Niu (CQMU: Chongqing Medical University)
view all 8 authors...
#1Donghao Sun (Peking Union Medical College)H-Index: 1
#2Xuetao Cao (Peking Union Medical College)H-Index: 69
Last.Chunmei Wang (Peking Union Medical College)
view all 3 authors...
#1Kinga Kochan-Jamrozy (Gdańsk Medical University)H-Index: 1
#2Jarosław Króliczewski (Gdańsk Medical University)H-Index: 7
Last.Rafal Bartoszewski (Gdańsk Medical University)H-Index: 19
view all 5 authors...
View next paperSUMO-Specific Protease 1 Is Essential for Stabilization of HIF1α during Hypoxia