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Plasma phospholipid trans fatty acids and risk of heart failure

Published on Apr 1, 2013in The American Journal of Clinical Nutrition6.57
· DOI :10.3945/ajcn.112.050120
Oluwabunmi Tokede8
Estimated H-index: 8
(Harvard University),
Andrew B. Petrone11
Estimated H-index: 11
(Harvard University)
+ 5 AuthorsLuc Djoussé58
Estimated H-index: 58
(Harvard University)
Cite
Abstract
Background: Although trans fatty acids (TFAs) may increase the risk of dyslipidemia and coronary artery disease (CAD), limited data are available on their association with heart failure (HF). Objective: Our goal was to assess associations of plasma and dietary TFAs with HF and CAD. Design: We used a prospective, nested case-control design to select 788 incident HF cases and 788 matched controls from the Physicians’ Health Study for biomarker analyses and a prospective cohort for the dietary analyses. Plasma fatty acids were assessed by using gas chromatography, and dietary intake was estimated by using a food-frequency questionnaire. Self-reported HF was ascertained by using annual follow-up questionnaires with validation in a subsample. We used conditional logistic (or Cox) regression to estimate multivariable-adjusted ORs (or HRs) for HF and CAD. Results: Multivariable-adjusted ORs (95% CIs) for HF across consecutive quintiles of plasma trans 18:2 (linoleic acid) fatty acids were 1.0 (reference), 1.10 (0.79, 1.54), 0.88 (0.62, 1.25), 0.71 (0.49, 1.02), and 0.67 (0.45, 0.98) (P-trend = 0.01). Each SD of plasma trans 18:2 was associated with a 22% lower risk of HF (95% CI: 6%, 36%). Plasma trans 16:1 and 18:1 were not associated with risk of HF (P > 0.05). Dietary trans fats were not associated with incident HF or CAD. Conclusions: Our data are consistent with a lower risk of HF with higher concentrations of plasma trans 18:2 but not with trans 16:1 or trans 18:1 fatty acids in male physicians. Dietary TFAs were not related to incident HF or CAD.
  • References (43)
  • Citations (14)
Cite
References43
Newest
Published on Jun 15, 2012in Obesity3.97
Luc Djoussé58
Estimated H-index: 58
(Brigham and Women's Hospital),
Jemma B. Wilk39
Estimated H-index: 39
(Brigham and Women's Hospital)
+ 3 AuthorsJohn Michael Gaziano113
Estimated H-index: 113
(Brigham and Women's Hospital)
Limited data are available on the association between adiponectin and incident heart failure. In the current ancillary study to the Physicians' Health Study, we used a prospective nested-case control design to examine whether plasma adiponectin concentration was related to the risk of heart failure. We selected 787 incident heart failure cases and 787 matched controls for the current analysis. Each control was selected using a risk set sampling technique at the time of the occurrence of the inde...
Published on Jan 3, 2012in Circulation23.05
Veronique Lee Roger96
Estimated H-index: 96
,
Alan S. Go90
Estimated H-index: 90
+ 34 AuthorsCaroline S. Fox124
Estimated H-index: 124
Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .e3 1. About These Statistics. . . . . . . . . . . . . . . . . . . . . . . . . .e7 2. American Heart Association's 2020 Impact Goals . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .e10 3. Cardiovascular Diseases . . . . . . . . . . . . . . . . . . . . . . .e21 4. Subclinical Atherosclerosis . . . . . . . . . . . . . . . . . . . . .e45 5. Coronary Heart Disease, Acute Coronary Syndrome, and Angina Pecto...
Published on Jan 1, 2012in Cardiovascular Research7.01
Tatiana Galvao6
Estimated H-index: 6
(UMB: University of Maryland, Baltimore),
Bethany H. Brown8
Estimated H-index: 8
(UMB: University of Maryland, Baltimore)
+ 7 AuthorsWilliam C. Stanley51
Estimated H-index: 51
(UMB: University of Maryland, Baltimore)
Aims The impact of a high-fat diet on the failing heart is unclear, and the differences between polyunsaturated fatty acids (PUFA) and saturated fat have not been assessed. Here, we compared a standard low-fat diet to high-fat diets enriched with either saturated fat (palmitate and stearate) or PUFA (linoleic and α-linolenic acids) in hamsters with genetic cardiomyopathy. Methods and results Male δ-sarcoglycan null Bio TO2 hamsters were fed a standard low-fat diet (12% energy from fat), or high-...
Published on Jul 1, 2011in Advances in Nutrition7.24
Sarah K Gebauer7
Estimated H-index: 7
(ARS: Agricultural Research Service),
J.M. Chardigny18
Estimated H-index: 18
(INRA: Institut national de la recherche agronomique)
+ 4 AuthorsDavid Baer39
Estimated H-index: 39
(ARS: Agricultural Research Service)
There are 2 predominant sources of dietary trans fatty acids (TFA) in the food supply, those formed during the industrial partial hydrogenation of vegetable oils (iTFA) and those formed by biohydrogenation in ruminants (rTFA), including vaccenic acid (VA) and the naturally occurring isomer of conjugated linoleic acid, cis-9, trans-11 CLA (c9,t11-CLA). The objective of this review is to evaluate the evidence base from epidemiological and clinical studies to determine whether intake of rTFA isomer...
Published on Feb 1, 2011in Circulation23.05
Veronique Lee Roger96
Estimated H-index: 96
,
Alan S. Go90
Estimated H-index: 90
+ 38 AuthorsEarl S. Ford110
Estimated H-index: 110
Published on Aug 1, 2010in European Journal of Preventive Cardiology5.64
Constantine I. Vardavas23
Estimated H-index: 23
(UM: Maastricht University),
Manolis Linardakis19
Estimated H-index: 19
(UoC: University of Crete)
+ 2 AuthorsAnthony Kafatos50
Estimated H-index: 50
(UoC: University of Crete)
Background Farmers from Crete as first studied within the framework of the Seven Countries Study, were historically known for holding the title of the ‘gold standard’ of health status globally and had a very low prevalence of both cardiovascular disease (CVD) and cancer. Taking the above into account we evaluated the changes in CVD risk factors among farmers in Crete, Greece and compared our findings with data from the 1960s.Design Cross-sectional.Methods Five hundred and two farmers (18–79 year...
Published on Apr 1, 2010in The American Journal of Clinical Nutrition6.57
Renata Micha38
Estimated H-index: 38
(Harvard University),
Irena B. King41
Estimated H-index: 41
(UNM: University of New Mexico)
+ 5 AuthorsDariush Mozaffarian113
Estimated H-index: 113
(Harvard University)
Background: The overall consumption of trans fatty acids (TFAs) increases the risk of coronary artery disease. However, multiple TFA isomers exist, each with potentially different health effects. Different food sources of these specific TFA isomers are not well established. Objective: Our objective was to determine the major independent food sources of specific TFA isomers. Design: We investigated relations of major potential food sources of TFAs, as assessed by serial food-frequency questionnai...
Published on Apr 13, 2009in JAMA Internal Medicine20.77
Andrew Mente30
Estimated H-index: 30
,
Lawrence de Koning12
Estimated H-index: 12
+ 1 AuthorsSonia S. Anand74
Estimated H-index: 74
Background: Although a wealth of literature links dietaryfactorsandcoronaryheartdisease(CHD),thestrength oftheevidencesupportingvalidassociationshasnotbeen evaluated systematically in a single investigation. Methods: We conducted a systematic search of MEDLINE for prospective cohort studies or randomized trials investigating dietary exposures in relation to CHD. We used the Bradford Hill guidelines to derive a causation score based on 4 criteria (strength, consistency, temporality, and coherence...
Published on Jan 1, 2009in The American Journal of Clinical Nutrition6.57
Mitra Saadatian-Elahi11
Estimated H-index: 11
(IARC: International Agency for Research on Cancer),
Nadia Slimani80
Estimated H-index: 80
(IARC: International Agency for Research on Cancer)
+ 44 AuthorsPetra H.M. Peeters99
Estimated H-index: 99
(Imperial College London)
Background: Plasma phospholipid fatty acids have been correlated with food intakes in populations with homogeneous dietary patterns. However, few data are available on populations with heterogeneous dietary patterns. Objective: The objective was to investigate whether plasma phospholipid fatty acids are suitable biomarkers of dietary intakes across populations involved in a large European multicenter study. Design: A cross-sectional study design nested to the European Prospective Investigation i...
Published on Nov 12, 2008in JAMA51.27
Howard D. Sesso68
Estimated H-index: 68
,
Julie E. Buring155
Estimated H-index: 155
+ 7 AuthorsJohn Michael Gaziano113
Estimated H-index: 113
Context Basic research and observational studies suggest vitamin E or vitamin C may reduce the risk of cardiovascular disease. However, few long-term trials have evaluated men at initially low risk of cardiovascular disease, and no previous trial in men has examined vitamin C alone in the prevention of cardiovascular disease. Objective To evaluate whether long-term vitamin E or vitamin C supplementation decreases the risk of major cardiovascular events among men. Design, Setting, and Participant...
Cited By14
Newest
Published on Jun 1, 2019in Nutrition Research Reviews5.59
Conor P. Kerley1
Estimated H-index: 1
Growing evidence has emerged about the role of dietary patterns and components in heart failure (HF) incidence and severity. The objective here is to provide a comprehensive summary of the current evidence regarding dietary patterns/components and HF. A comprehensive search of online databases was conducted using multiple relevant keywords to identify relevant human studies. The Dietary Approaches to Stop Hypertension (DASH) and Mediterranean diets have consistently been associated with decrease...
Published on Oct 10, 2018in Nutrition Reviews5.78
Ilse G. Pranger2
Estimated H-index: 2
(UMCG: University Medical Center Groningen),
Monica L. Joustra2
Estimated H-index: 2
(UMCG: University Medical Center Groningen)
+ 5 AuthorsStephan J. L. Bakker59
Estimated H-index: 59
(UMCG: University Medical Center Groningen)
Published on Sep 1, 2018in Health & Place3.20
Stephen J. Mooney11
Estimated H-index: 11
(UW: University of Washington),
Rozenn N. Lemaitre60
Estimated H-index: 60
(UW: University of Washington)
+ 7 AuthorsGina S. Lovasi30
Estimated H-index: 30
(Drexel University)
Abstract We explored links between food environments, dietary intake biomarkers, and sudden cardiac arrest in a population-based longitudinal study using cases and controls accruing between 1990 and 2010 in King County, WA. Surprisingly, presence of more unhealthy food sources near home was associated with a lower 18:1 trans -fatty acid concentration (−0.05% per standard deviation higher count of unhealthy food sources, 95% Confidence Interval [CI]: 0.01, 0.09). However, presence of more unhealt...
Published on May 3, 2018in Critical Reviews in Food Science and Nutrition6.70
Jingjing Liang1
Estimated H-index: 1
(SYSU: Sun Yat-sen University),
Quan Zhou1
Estimated H-index: 1
(Guangzhou Medical University)
+ 2 AuthorsZheqing Zhang1
Estimated H-index: 1
(Southern Medical University)
ABSTRACTBackground: Circulating biomarkers of dairy fat provide objective measures of dairy fat intake and facilitate conclusions relevant to populations with different diets and susceptibility to cardiovascular diseases (CVD).Objective: To assess the relationship between circulating pentadecanoic acid (15:0), heptadecanoic acid (17:0) and trans-palmitoleic acid (trans-16:1n-7) and the risk of CVD.Methods: Pubmed, Medline and Embase were searched for prospective cohort studies of the relationshi...
Published on Apr 1, 2017in European Journal of Nutrition4.45
Rafael Longhi2
Estimated H-index: 2
(UFRGS: Universidade Federal do Rio Grande do Sul),
Roberto Farina de Almeida9
Estimated H-index: 9
(UFRGS: Universidade Federal do Rio Grande do Sul)
+ 6 AuthorsDiogo O. Souza59
Estimated H-index: 59
(UFRGS: Universidade Federal do Rio Grande do Sul)
Purpose Recent data regarding trans fatty acids (TFAs) have implicated these lipids as particularly deleterious to human health, causing systemic inflammation, endothelial dysfunction and possibly inflammation in the central nervous system (CNS). We aimed to clarify the impact of partially hydrogenated soybean oil (PHSO) with different TFA concentrations on cerebrospinal fluid (CSF), serum and hepatic parameters in adult Wistar rats.
Published on Sep 9, 2016in Critical Reviews in Food Science and Nutrition6.70
Katrin Kuhnt12
Estimated H-index: 12
(FSU: University of Jena),
Christian Degen10
Estimated H-index: 10
(FSU: University of Jena),
Gerhard Jahreis37
Estimated H-index: 37
(FSU: University of Jena)
The definition and evaluation of trans fatty acids (TFA) with regard to foodstuffs and health hazard are not consistent. Based on the current situation, the term should be restricted only to TFA with isolated double bonds in trans-configuration. Conjugated linoleic acids (CLA) should be separately assessed. Ideally, the origin of the consumed fat should be declared, i.e., ruminant TFA (R-TFA) and industrial TFA (non-ruminant; I-TFA). In ruminant fat, more than 50% of R-TFA consists of vaccenic a...
Published on Sep 1, 2016in Atherosclerosis4.25
Marcus E. Kleber47
Estimated H-index: 47
(Heidelberg University),
Graciela Delgado21
Estimated H-index: 21
(Heidelberg University)
+ 2 AuthorsClemens von Schacky26
Estimated H-index: 26
(LMU: Ludwig Maximilian University of Munich)
Background Saturated fatty acids are thought to be harmful by increasing the risk for cardiovascular events. Objective We examined the associations of erythrocyte saturated fatty acids with total and cardiovascular mortality in patients referred for coronary angiography. Methods Red blood cell saturated fatty acid (RBC SFA) proportions were measured by gas chromatography at baseline in 3259 participants of the Ludwigshafen Risk and Cardiovascular Health study. Associations of saturated fatty aci...
Published on Apr 1, 2016in European Heart Journal23.24
Marcus E. Kleber47
Estimated H-index: 47
(Heidelberg University),
Graciela Delgado21
Estimated H-index: 21
(Heidelberg University)
+ 2 AuthorsClemens von Schacky26
Estimated H-index: 26
(LMU: Ludwig Maximilian University of Munich)
Aims Trans -fatty acids (TFAs) are generated by the food industry and also occur naturally in trace amounts in dairy products. For the latter, beneficial health effects have been claimed, while there are numerous reports about TFA of industrial origin being hazardous to human health. Therefore, we aimed to investigate the association of TFA with mortality in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. Methods and results The fatty acid composition of erythrocyte membranes was ...
Published on Jan 1, 2016
Farid Menaa10
Estimated H-index: 10
,
Bouzid Menaa13
Estimated H-index: 13
+ 1 AuthorsAbder Menaa6
Estimated H-index: 6
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