Match!

Systematic review of neurocognition and occupational functioning in major depressive disorder

Published on Feb 1, 2013
· DOI :10.2217/npy.13.3
Vanessa C. Evans3
Estimated H-index: 3
(UBC: University of British Columbia),
Sarah Sl Chan1
Estimated H-index: 1
(UBC: University of British Columbia)
+ 3 AuthorsRaymond W. Lam60
Estimated H-index: 60
(UBC: University of British Columbia)
Abstract
Occupational impairment accounts for much of the burden and economic costs associated with major depressive disorder (MDD). Many studies have documented neurocognitive deficits in MDD, and depression-associated cognitive dysfunction would be expected to have significant effects on occupational functioning. We systematically reviewed the literature for studies on neurocognition and occupational functioning in MDD. Electronic databases (e.g., MEDLINE, PsychInfo and Cochrane Clinical Trials) were searched using appropriate terms and bibliographies of relevant publications were scanned for additional citations. Two reviewers independently reviewed papers for inclusion and data extraction, with conflicts resolved by consensus. Inclusion criteria were diagnosis of MDD using validated criteria (e.g., DSM‑IV or ICD‑10), use of objective neuropsychological tests and use of a specific measure of occupational functioning. Of 630 citations identified in the initial search, only two studies met inclusion criteria and were included in a qualitative review. Both had significant methodological limitations. Nonetheless, the depressed samples had significant neurocognitive deficits that were associated with employment status and work impairment. Neurocognitive dysfunction is probably associated with impairment in occupational functioning in individuals with MDD, but the evidence is limited. Further research should examine specific cognitive domains, and use validated measures of work functioning and productivity.
  • References (55)
  • Citations (22)
📖 Papers frequently viewed together
316 Citations
249 Citations
50 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References55
Newest
#1Raymond W. Lam (UBC: University of British Columbia)H-Index: 60
#2Erin E. Michalak (UBC: University of British Columbia)H-Index: 27
Last. Lakshmi N. Yatham (UBC: University of British Columbia)H-Index: 64
view all 6 authors...
Background. Major depressive disorder (MDD) is associated with significant impairment in occupational functioning. This study sought to determine which depressive symptoms and medication side effects were perceived by patients with MDD to have the greatest interference on work functioning. Methods. 164 consecutive patients with MDD by DSM-IV criteria completed a standard assessment that included a self-rated questionnaire about the degree to which symptoms and side effects interfered with work f...
33 CitationsSource
#1Stefanie WagnerH-Index: 17
#2B. DoeringH-Index: 1
Last. André TadićH-Index: 22
view all 5 authors...
Wagner S, Doering B, Helmreich I, Lieb K, Tadic A. A meta-analysis of executive dysfunctions in unipolar major depressive disorder without psychotic symptoms and their changes during antidepressant treatment. Objective: Empirical evidence supports the existence of significant executive deficits in patients with major depressive disorder (MDD) as compared to non-depressed controls. Nevertheless, the effect size of executive dysfunctions in unipolar, non-psychotic MDD as well as their relationship...
83 CitationsSource
#1Julie Godard (Laval University)H-Index: 2
#2Philippe BaruchH-Index: 2
Last. Martin F. LafleurH-Index: 2
view all 4 authors...
50 CitationsSource
Objectives: During the past decade, common mental disorders (CMD) have emerged as a major public and occupational health problem in many countries. Several instruments have been developed to measure the influence of health on functioning at work. To select appropriate instruments for use in occupational health practice and research, the measurement properties (eg, reliability, validity, responsiveness) must be evaluated. The objective of this study is to appraise critically and compare the measu...
31 CitationsSource
#1Carolyn S. Dewa (U of T: University of Toronto)H-Index: 32
#2Angus H. Thompson (U of A: University of Alberta)H-Index: 14
Last. Phillip Jacobs (U of A: University of Alberta)H-Index: 4
view all 3 authors...
Objective:About one-third of the annual $51 billion cost of mental illnesses is related to productivity losses. However, few studies have examined the association of treatment and productivity. The purpose of our research is to examine the association of depression and its treatment and work productivity.Methods:Our analyses used data from 2737 adults aged between 18 and 65 years who participated in a large-scale community survey of employed and recently employed people in Alberta. Using the Wor...
39 CitationsSource
#1Julie Godard (Laval University)H-Index: 2
#2Simon Grondin (Laval University)H-Index: 30
Last. Martin F. LafleurH-Index: 2
view all 4 authors...
Abstract Previous studies have revealed psychosocial and cognitive impairments in patients during depression. The primary aim of this study was to investigate whether patients with major depression (MDD) and bipolar disorder (BD) differ in psychosocial and neurocognitive profiles. A second aim was to examine whether cognitive impairments are homogeneous among depressed patients. Patients with MDD ( n =16) and BD ( n =14) were enrolled during a major depressive episode. About half of them had com...
66 CitationsSource
Abstract Background It is unclear whether cognitive impairment is prevalent in the remitted state of unipolar disorder. Aim To evaluate whether cognitive function is impaired in the remitted state in patients with unipolar depression compared with healthy control individuals, and to investigate the association to prior course of illness, i.e. the number, duration and severity of prior depressive episodes. Method Systematic search on existing on-line databases and hand-search of original publishe...
209 CitationsSource
#1Raymond W. Lam (UBC: University of British Columbia)H-Index: 60
#2Marie-Josée Filteau (Laval University)H-Index: 3
Last. Roumen Milev (Queen's University)H-Index: 23
view all 3 authors...
Abstract Background Major depressive disorder (MDD) is associated with significant impairment in quality of life and psychosocial functioning, including social and occupational/role functioning. Evaluation of clinical effectiveness of treatments for depression must include improvement in these important functional outcomes. However, clinical trials for depression have primarily focused on reduction in symptoms, as measured by symptom severity scales such as the HDRS and MADRS or by standard defi...
56 CitationsSource
#1Grant L. Iverson (UBC: University of British Columbia)H-Index: 70
#2Brian L. Brooks (U of C: University of Calgary)H-Index: 4
Last. Allan H. Young (UBC: University of British Columbia)H-Index: 77
view all 4 authors...
Background We hypothesized that only a minority of patients with mood disorders have measurable cognitive impairment, and this minority drives the small-to-medium effect sizes detected in group studies. Removal of this minority from group statistical analyses will illustrate that the majority appear to have broadly normal cognitive functioning.
69 CitationsSource
Objective: The objective of this commentary is to discuss the issues surrounding the concept of presenteeism, including the measurement of lost work time per individual, the conversion of the scores attained by the instruments into expressions of productivity loss, and the translation of productivity losses into economic outcomes. Methods: Literature searches using PubMed and MEDLINE were conducted using “presenteeism” and “productivity” as keywords and combined with other studies known to the a...
84 CitationsSource
Cited By22
Newest
#2Maggie McCue (Takeda Pharmaceutical Company)H-Index: 3
Last. Jennifer H. BarnettH-Index: 25
view all 10 authors...
BACKGROUND: Cognitive symptoms are common in major depressive disorder and may help to identify patients who need treatment or who are not experiencing adequate treatment response. Digital tools providing real-time data assessing cognitive function could help support patient treatment and remediation of cognitive and mood symptoms. OBJECTIVE: The aim of this study was to examine feasibility and validity of a wearable high-frequency cognitive and mood assessment app over 6 weeks, corresponding to...
1 CitationsSource
#1Abebe AmbawH-Index: 1
#2Getachew Tesfaw Desalegn (University of Gondar)H-Index: 1
Objective Cognitive impairments are now widely recognized and emerging as an important therapeutic target in a patient with a major depressive disorder (MDD). It associated with a more deteriorating course of illness among MDD patients. Therefore, understanding the level of cognitive impairment and associated factors is crucial to provide optimal care for MDD patients.
Source
#1Kassahun Habtamu (AAU: Addis Ababa University)H-Index: 5
#2Girmay Medhin (AAU: Addis Ababa University)H-Index: 38
Last. Abebaw Fekadu (BSMS: Brighton and Sussex Medical School)H-Index: 30
view all 6 authors...
There have been few studies examining the functioning of clinically-diagnosed people with depression in primary healthcare (PHC) in low- and middle-income countries (LMICs). The aim of this study was to identify factors associated with functional impairment among people diagnosed with depression in PHC in Ethiopia as part of implementation of a task-shared model of mental healthcare. A comparative cross-sectional study was conducted. As part of the Programme for Improving Mental health carE (PRI...
Source
#1Raymond W. Lam (UBC: University of British Columbia)H-Index: 60
#2Carol Persad (UM: University of Michigan)H-Index: 22
Major depressive disorder (MDD) is a common and burdensome mental health condition that is associated with significant occupational disability. Cognitive dysfunction, especially in neurocognitive domains of attention, memory, and executive functioning, is a well-recognized core feature of MDD that contributes to impairment in work functioning. Although there are many evidence-based treatments for MDD, neurocognitive deficits can persist even when other depressive symptoms are in remission after ...
Source
#1ShiYue Peng (CQMU: Chongqing Medical University)
#2Jing Li (CQMU: Chongqing Medical University)
view all 7 authors...
ABSTRACTThis study aims to explore the characteristics and risk factors of cognitive impairment in adolescent patients with first-episode depression. In total, 128 adolescents with first-episode depression were selected (patient group). Clinical factors, including gender, educational level, suicide risk, sleep status based on the Pittsburg Sleep Quality Index scale (PSQI), and disease duration based on Hamilton Rating Scale for Depression (HRSD), were assessed to identify risk factors. The MATRI...
Source
#1Laura Damiani Branco (PUCRS: Pontifícia Universidade Católica do Rio Grande do Sul)H-Index: 7
#2Charles Cotrena (PUCRS: Pontifícia Universidade Católica do Rio Grande do Sul)H-Index: 8
Last. Rochele Paz Fonseca (PUCRS: Pontifícia Universidade Católica do Rio Grande do Sul)H-Index: 17
view all 6 authors...
Objective: This study aimed to examine the accuracy in identifying facial expressions and the perceived intensity of emotions of happiness, sadness, disgust, anger, fear, surprise in bipolar disorder (BD), and major depressive disorder (MDD). Method: Ninety-three adult participants (n = 30 BD, 80% female; n = 18 MDD, 72.2% female; n = 45 C, 46.7% female) completed a facial expression task. Stimuli in the task were first presented for 200 ms, followed by 500 ms, and 1000 ms. Participants were ask...
1 CitationsSource
#1Adriano José Maia Chaves Filho (UFC: Federal University of Ceará)H-Index: 7
#2Camila Nayane de Carvalho Lima (UFC: Federal University of Ceará)H-Index: 6
Last. Danielle Silveira Macêdo (UFC: Federal University of Ceará)H-Index: 27
view all 6 authors...
Obesity and depression are among the most pressing health problems in the contemporary world. Obesity and depression share a bidirectional relationship, whereby each condition increases the risk of the other. By inference, shared pathways may underpin the comorbidity between obesity and depression. Activation of cell-mediated immunity (CMI) is a key factor in the pathophysiology of depression. CMI cytokines, including IFN-γ, TNFα and IL-1β, induce the catabolism of tryptophan (TRY) by stimulatin...
16 CitationsSource
Background: Cognitive dysfunction is a predominant symptom of Major Depressive Disorder (MDD), contributing to functional impairment. Objective: The primary objective of this study was to assess and describe perceived cognitive dysfunction amongst Asian patients diagnosed with MDD. The secondary objective was to explore the associations between depression severity, perceived cognitive dysfunction and functional disability. Methods: This was a multi-country, multi-centre, cross-sectional study. A...
3 CitationsSource
#1Charles Cotrena (PUCRS: Pontifícia Universidade Católica do Rio Grande do Sul)H-Index: 8
#2Laura Damiani Branco (PUCRS: Pontifícia Universidade Católica do Rio Grande do Sul)H-Index: 7
Last. Rochele Paz Fonseca (PUCRS: Pontifícia Universidade Católica do Rio Grande do Sul)H-Index: 17
view all 5 authors...
Objectives: Cognitive dysfunction is a key feature of major depressive (MDD) and bipolar (BD) disorders. However, rather than a single cognitive profile corresponding to each diagnostic categories, recent studies have identified significant intra- and cross-diagnostic variability in patterns of cognitive impairment. The goal of this study was to contribute to the literature on cognitive heterogeneity in mood disorders by identifying cognitive subprofiles in a population of patients with MDD, BD ...
6 CitationsSource
#1Amanda R. Mathew (NU: Northwestern University)H-Index: 11
#2Lee Hogarth (University of Exeter)H-Index: 27
Last. Brian Hitsman (NU: Northwestern University)H-Index: 26
view all 5 authors...
Background and aims Despite decades of research on co-occurring smoking and depression, cessation rates remain consistently lower for depressed smokers than for smokers in the general population, highlighting the need for theory-driven models of smoking and depression. This paper provides a systematic review with a particular focus on psychological states that disproportionately motivate smoking in depression, and frame an incentive learning theory account of smoking-depression co-occurrence. Me...
50 CitationsSource