Defective DNA Replication Impairs Mitochondrial Biogenesis In Human Failing Hearts

Mitochondrial dysfunction plays a pivotal role in the development of heart failure. Animal studies suggest that impaired mitochondrial biogenesis attributable to downregulation of the peroxisome proliferator-activated receptor gamma coactivator (PGC)-1 transcriptional pathway is integral of mitochondrial dysfunction in heart failure.The study sought to define mechanisms underlying the impaired mitochondrial biogenesis and function in human heart...