Original paper
Excessive centrifugal fields damage high density lipoprotein [S]
Abstract
HDL is typically isolated ultracentrifugally at 40,000 rpm or greater, however, such high centrifugal forces are responsible for altering the recovered HDL particle. We demonstrate that this damage to HDL begins at approximately 30,000 rpm and the magnitude of loss increases in a rotor speed-dependent manner. The HDL is affected by elevated ultracentrifugal fields resulting in a lower particle density due to the shedding of associated proteins....
Paper Details
Title
Excessive centrifugal fields damage high density lipoprotein [S]
Published Date
Jun 1, 2015
Journal
Volume
56
Issue
6
Pages
1172 - 1181
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Notes
History