Review paper
Mitochondrial DNA repair and association with aging – An update
Abstract
Mitochondrial DNA is constantly exposed to oxidative injury. Due to its location close to the main site of reactive oxygen species, the inner mitochondrial membrane, mtDNA is more susceptible than nuclear DNA to oxidative damage. The accumulation of DNA damage is thought to play a critical role in the aging process and to be particularly deleterious in post-mitotic cells. Thus, DNA repair is an important mechanism for maintenance of genomic...
Paper Details
Title
Mitochondrial DNA repair and association with aging – An update
Published Date
Aug 1, 2010
Journal
Volume
45
Issue
7-8
Pages
478 - 488
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