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Experimental Gerontology
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#1Ryszard ZarzecznyH-Index: 2
#2Anna PolakH-Index: 11
Last. Ahmed ManasarH-Index: 1
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Abstract Background Bone turnover markers (BTM) reflect the status of bone remodeling processes responsible for bone mineral density. The existing body of evidence that osseous tissue can interact with many other body tissues and organs suggests that the cross-talks can lead to different relationships. The biological traits associated with BTMs have not been thoroughly studied in the elderly despite bone turnover being known to increase with age. Objective To determine whether the C-terminal cro...
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#1Akito Yoshiko (Chukyo University)H-Index: 5
Last. Kohei Watanabe (Chukyo University)H-Index: 16
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Abstract Total hip arthroplasty (THA) is performed for pain relief in patients with osteoarthritis of the hip joint. After THA, patients may recover muscle mass and physical function. Muscle quality is the main parameter used to indicate intramuscular fat content, and it is related with muscle function in older individuals. However, how THA affects muscle quality, as determined by echo intensity (EI), is not well understood. The purpose of this study was to determine the long-term characteristic...
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#1Sebastiaan Dalle (Katholieke Universiteit Leuven)H-Index: 1
#2Katrien Koppo (Katholieke Universiteit Leuven)H-Index: 22
Abstract Muscle loss is an important feature that occurs in multiple pathologies including osteoarthritis (OA), chronic obstructive pulmonary disease (COPD) and type II diabetes (T2D). Despite differences in pathogenesis and disease-related complications, there are reasons to believe that some fundamental underlying mechanisms are inherent to the muscle wasting process, irrespective of the pathology. Recent evidence shows that inflammation, either local or systemic, contributes to the modulation...
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#1Alex M. Noonan (U of G: University of Guelph)H-Index: 1
#2Nicole Mazara (U of G: University of Guelph)
Last. Stephen H.M. Brown (U of G: University of Guelph)H-Index: 10
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Abstract Purpose Studies have revealed an age-related decrease in the ability to produce force as well as an increase in the contractile stiffness and passive stress of single muscle fibres. However, further insight into age-related changes to the passive properties of human skeletal muscles is needed. The aim of this study was to characterize single muscle fibre passive properties from young and old males across a physiologic range of sarcomere lengths (SLs). Methods Ten young ([YM]: mean age: ...
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#1Eric J Gangloff (Ohio Wesleyan University)
#2Tonia S. Schwartz (Iowa State University)H-Index: 19
Last. Anne M. Bronikowski (Iowa State University)H-Index: 17
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As a pacesetter for physiological processes, variation in metabolic rate can determine the shape of energetic trade-offs and thereby drive variation in life-history traits. In turn, such variation in metabolic performance and life-histories can have profound consequences for lifespan and lifetime fitness. Thus, the extent to which metabolic rate variation is due to phenotypic plasticity or fixed genetic differences among individuals or populations is likely to be shaped by natural selection. Her...
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#1Jeonghyun Oh (Chosun University)H-Index: 1
#2Cha Kyung Youn (Chosun University)H-Index: 4
Last. Sung Il Cho (Chosun University)H-Index: 6
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Abstract An increase in mitochondrial damage has been associated with a decline in the ability to mitigate damage through mitophagy in age-related pathologies. The present study aimed to investigate the changes of mitophagy in a mouse model with age-related hearing loss. C57BL/6J mice were divided into two groups: young (1 month) and aged (12 months). Hearing tests were conducted through the measurement of auditory brainstem response (ABR). Mitochondrial DNA copy number, the level of mitochondri...
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#1Flávio V. Machado (UnB: University of Brasília)
#2Luciana Lilian Louzada (UnB: University of Brasília)H-Index: 5
Last. Otávio de Tolêdo Nóbrega (UnB: University of Brasília)H-Index: 21
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Zolpidem is widely used to treat insomnia of older adults despite that few randomized controlled studies were conducted in this group. We systematically reviewed the relevant literature on efficacy/effectiveness and safety of zolpidem use by elderly individuals in relevant databases completed with a manual search of key journals. Studies were required to include individuals aged >/=60 years under intervention with zolpidem compared to placebo or other hypnosedatives. Outcomes were either objecti...
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#1Ryan N. Marshall (University of Birmingham)
#2Paul Morgan (University of Birmingham)
Last. Leigh Breen (University of Birmingham)H-Index: 26
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Abstract Background Understanding the root cause of the age-related impairment in muscle adaptive remodelling with resistance exercise training (RET) and developing pragmatic and accessible resistance exercise for older adults, are essential research directives. Methods We sought to determine whether indices of quadriceps muscle EMG activity in response to different modes of RET and activities of daily living (ADL), differed between 15 healthy younger (25 ± 3 years) and 15 older (70 ± 5 years) a...
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#1Anahid Ebrahimi (UW: University of Wisconsin-Madison)H-Index: 1
#2Isaac F. Loegering (UW: University of Wisconsin-Madison)H-Index: 1
Last. Darryl G. Thelen (UW: University of Wisconsin-Madison)H-Index: 39
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The purpose of this study was to investigate age-related differences in Achilles tendon loading during gait. Fourteen young (7F/7M, 26+/-5years) and older (7F/7M, 67+/-5years) adults without current neurological or orthopaedic impairment participated. Shear wave tensiometry was used to measure tendon stress by tracking Achilles tendon wave speed. The wave speed-stress relationship was calibrated using simultaneous tensiometer and force plate measures during a standing sway task. Tendon stress wa...
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Top fields of study
Endocrinology
Longevity
Ageing
Senescence
Diabetes mellitus
Biology