SIRT 2 induces the checkpoint kinase BubR1 to increase lifespan
Abstract
Mice overexpressing the mitotic checkpoint kinase gene BubR1 live longer, whereas mice hypomorphic for BubR1 (BubR1 H/H ) live shorter and show signs of accelerated aging. As wild‐type mice age, BubR1 levels decline in many tissues, a process that is proposed to underlie normal aging and age‐related diseases. Understanding why BubR1 declines with age and how to slow this process is therefore of considerable interest. The sirtuins ( SIRT 1‐7) are...
Paper Details
Title
Published Date
May 13, 2014
Journal
Volume
33
Issue
13
Pages
1438 - 1453
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