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The EMBO Journal
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#1Carlos Conde (University of Porto)H-Index: 12
#2Reto Gassmann (University of Porto)H-Index: 18
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#1Thomas Kruse (UCPH: University of Copenhagen)H-Index: 8
#2Sebastian P. Gnosa (UCPH: University of Copenhagen)H-Index: 1
Last. Jeanette Schwarz (UCPH: University of Copenhagen)H-Index: 2
view all 15 authors...
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#1Ximena Soto (University of Manchester)H-Index: 5
#2Veronica Biga (University of Manchester)H-Index: 4
Last. Nancy Papalopulu (University of Manchester)H-Index: 38
view all 7 authors...
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#1Zichuan Liu (FMI: Friedrich Miescher Institute for Biomedical Research)H-Index: 5
#2Mathieu Tardat (FMI: Friedrich Miescher Institute for Biomedical Research)H-Index: 3
Last. Antoine Hfm Peters (University of Basel)
view all 7 authors...
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#1Xu Wang (Ha Tai: Xiamen University)H-Index: 3
#2Pengge Qian (Ha Tai: Xiamen University)H-Index: 2
Last. Jing Yuan (Ha Tai: Xiamen University)H-Index: 9
view all 5 authors...
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#1Hirotaka KanohH-Index: 3
#2Takahiro NittaH-Index: 2
Last. Koichi Fukase (Osaka University)H-Index: 48
view all 33 authors...
Innate immune signaling via TLR4 plays critical roles in pathogenesis of metabolic disorders, but the contribution of different lipid species to metabolic disorders and inflammatory diseases is less clear. GM3 ganglioside in human serum is composed of a variety of fatty acids, including long-chain (LCFA) and very-long-chain (VLCFA). Analysis of circulating levels of human serum GM3 species from patients at different stages of insulin resistance and chronic inflammation reveals that levels of VLC...
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#1Ziyou Lin (SYSU: Sun Yat-sen University)H-Index: 2
#2Yi Niu (SYSU: Sun Yat-sen University)H-Index: 2
Last. Chao Cheng (SYSU: Sun Yat-sen University)
view all 14 authors...
N6-methyladenosine (m(6) A) is an abundant nucleotide modification in mRNA, known to regulate mRNA stability, splicing, and translation, but it is unclear whether it is also has a physiological role in the intratumoral microenvironment and cancer drug resistance. Here, we find that METTL3, a primary m(6) A methyltransferase, is significantly down-regulated in human sorafenib-resistant hepatocellular carcinoma (HCC). Depletion of METTL3 under hypoxia promotes sorafenib resistance and expression o...
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#1Tatsuo Miyamoto (Hiroshima University)H-Index: 11
#2Kosuke Hosoba (Hiroshima University)H-Index: 4
Last. Shinya Matsuura (Hiroshima University)H-Index: 31
view all 9 authors...
Primary cilia are antenna-like organelles on the surface of most mammalian cells that receive sonic hedgehog (Shh) signaling in embryogenesis and carcinogenesis. Cellular cholesterol functions as a direct activator of a seven-transmembrane oncoprotein called Smoothened (Smo) and thereby induces Smo accumulation on the ciliary membrane where it transduces the Shh signal. However, how cholesterol is supplied to the ciliary membrane remains unclear. Here, we report that peroxisomes are essential fo...
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#1Volker Hartenstein (UCLA: University of California, Los Angeles)H-Index: 48
Macrophages are motile cells that roam the extracellular spaces within organs or the body cavity and carry out essential functions in organ development and immunity. New work published in The EMBO Journal adds surprising new insights into the heterogeneity of Drosophila macrophages revealing many similarities to their vertebrate counterparts.
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#1Nadia Hégarat (University of Sussex)H-Index: 10
#2Adrijana Crncec (University of Sussex)
Last. Masato T. Kanemaki (National Institute of Genetics)H-Index: 24
view all 14 authors...
Two mitotic cyclin types, cyclin A and B, exist in higher eukaryotes, but their specialised functions in mitosis are incompletely understood. Using degron tags for rapid inducible protein removal, we analyse how acute depletion of these proteins affects mitosis. Loss of cyclin A in G2-phase prevents mitotic entry. Cells lacking cyclin B can enter mitosis and phosphorylate most mitotic proteins, because of parallel PP2A:B55 phosphatase inactivation by Greatwall kinase. The final barrier to mitoti...
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