Original paper
Factors that influence telomeric oxidative base damage and repair by DNA glycosylase OGG1
Abstract
Telomeres are nucleoprotein complexes at the ends of linear chromosomes in eukaryotes, and are essential in preventing chromosome termini from being recognized as broken DNA ends. Telomere shortening has been linked to cellular senescence and human aging, with oxidative stress as a major contributing factor. 7,8-Dihydro-8-oxogaunine (8-oxodG) is one of the most abundant oxidative guanine lesions, and 8-oxoguanine DNA glycosylase (OGG1) is...
Paper Details
Title
Factors that influence telomeric oxidative base damage and repair by DNA glycosylase OGG1
Published Date
Jan 2, 2011
Journal
Volume
10
Issue
1
Pages
34 - 44
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Notes
History