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Published in DNA Repair3.71
Maryam Majidinia13
Estimated H-index: 13
(Urmia University of Medical Sciences),
Anupam Bishayee2
Estimated H-index: 2
(Lake Erie College of Osteopathic Medicine),
Bahman Yousefi17
Estimated H-index: 17
(Tabriz University of Medical Sciences)
Abstract DNA fidelity is constantly endangered by various types of intrinsic damages and extrinsic damages. Cells that are affected by DNA damage employ a specific, intricate, and interconnected network of cellular and molecular events (known as DNA damage response (DDR)) in order to maintain genome stability. More importantly, DDR is employed to pass intact genomes on to the next generation. Polyphenols constitute a large group of plant-based secondary metabolites widely present in foods and be...
Published in DNA Repair3.71
Marta Codrich (LMB: Laboratory of Molecular Biology), Marina Comelli10
Estimated H-index: 10
(University of Udine)
+ -3 AuthorsGianluca Tell40
Estimated H-index: 40
(LMB: Laboratory of Molecular Biology)
Abstract The pathogenesis of colorectal cancer (CRC) involves different mechanisms, such as genomic and microsatellite instabilities. Recently, a contribution of the base excision repair (BER) pathway in CRC pathology has been emerged. In this context, the involvement of APE1 in the BER pathway and in the transcriptional regulation of genes implicated in tumor progression strongly correlates with chemoresistance in CRC and in more aggressive cancers. In addition, the APE1 interactome is emerging...
Published in DNA Repair3.71
Zhenhua Shao1
Estimated H-index: 1
(Tohoku University),
Shinsuke Niwa12
Estimated H-index: 12
(Tohoku University)
+ -3 AuthorsYasukazu Daigaku11
Estimated H-index: 11
(Tohoku University)
Abstract In eukaryotes, the DNA damage bypass pathway is promoted by ubiquitylation of PCNA at the conserved lysine 164. Using CRISPR-Cas9 system, we introduced amino acid substitution at K165 of C. elegans PCNA that corresponds to K164 and examined the contribution of this residue at a variety of stages during development. In the presence of UV-induced DNA lesions, PCNA-K165 is crucial for not only the early embryonic stages but also during larval development, implicating its functions for a br...
Published on Jul 1, 2019in DNA Repair3.71
Karin C. Nitiss13
Estimated H-index: 13
(UIC: University of Illinois at Chicago),
John L. Nitiss34
Estimated H-index: 34
(UIUC: University of Illinois at Urbana–Champaign),
Leslyn Hanakahi3
Estimated H-index: 3
(UIUC: University of Illinois at Urbana–Champaign)
Abstract DNA topoisomerases are essential for DNA metabolic processes such as replication and transcription. Since DNA is double stranded, the unwinding needed for these processes results in DNA supercoiling and catenation of replicated molecules. Changing the topology of DNA molecules to relieve supercoiling or resolve catenanes requires that DNA be transiently cut. While topoisomerases carry out these processes in ways that minimize the likelihood of genome instability, there are several ways ...
Published in DNA Repair3.71
Chen-Hsin Kuo1
Estimated H-index: 1
(CGU: Chang Gung University),
Yann-Lii Leu29
Estimated H-index: 29
(CGU: Chang Gung University)
+ -3 AuthorsChin-Chuan Chen4
Estimated H-index: 4
(CGU: Chang Gung University)
Abstract Combining natural products with chemotherapy and/or radiotherapy may increase the efficacy of cancer treatment. It has been hypothesized that natural products may inhibit DNA repair and sensitize cancer cells to DNA damage-based cancer therapy. However, the molecular mechanisms underlying these activities remain unclear. In this study, we found that diallyl disulfide (DADS), an organosulfur compound, increased the sensitivity of yeast cells to DNA damage and has potential for developmen...
Published in DNA Repair3.71
Pierre Caron (LUMC: Leiden University Medical Center), Janette van der Linden (LUMC: Leiden University Medical Center), Haico van Attikum30
Estimated H-index: 30
(LUMC: Leiden University Medical Center)
Abstract DNA double-strand breaks (DSBs) affect chromatin integrity and impact DNA-dependent processes such as transcription. Several studies revealed that the transcription of genes located in close proximity to DSBs is transiently repressed. This is achieved through the establishment of either a transient repressive chromatin context or eviction of the RNA polymerase II complex from the damaged chromatin. While these mechanisms of transcription repression have been shown to affect the efficien...
Published on May 1, 2019in DNA Repair3.71
Amir Mohammadzadeh1
Estimated H-index: 1
,
Mohammad Mirza-Aghazadeh-Attari3
Estimated H-index: 3
+ 5 AuthorsMaryam Majidinia13
Estimated H-index: 13
Abstract Ageing is a sophisticated process, accompanied by reduction in general physiological capacity and increase in mortality and death, stemming from damage accumulation over time. Various signaling pathways are known to be involved in the functional decrease in various organs in ageing humans. One of the most prominent pathways is DNA damage response (DDR), which is responsible for maintenance of the genomic integrity and stability. Insufficient or dysfunctional DDR signaling and the subseq...
Published in DNA Repair3.71
Mara Sannai1
Estimated H-index: 1
(Fox Chase Cancer Center),
Valentina Doneddu2
Estimated H-index: 2
(University of Sassari)
+ -3 AuthorsAntonio Cigliano16
Estimated H-index: 16
(Fox Chase Cancer Center)
Abstract The base excision repair DNA N-glycosylase MBD4 (also known as MED1), an interactor of the DNA mismatch repair protein MLH1, plays a central role in the maintenance of genomic stability of CpG sites by removing thymine and uracil from G:T and G:U mismatches, respectively. MBD4 is also involved in DNA damage response and transcriptional regulation. The interaction with other proteins is likely critical for understanding MBD4 functions. To identify novel proteins that interact with MBD4, ...
Published in DNA Repair3.71
Jan Jamroskovic2
Estimated H-index: 2
(Umeå University),
Ikenna R. Obi6
Estimated H-index: 6
(Umeå University)
+ -3 AuthorsNasim Sabouri10
Estimated H-index: 10
(Umeå University)
Abstract In order to understand in which biological processes the four-stranded G-quadruplex (G4) DNA structures play a role, it is important to determine which predicted regions can actually adopt a G4 structure. Here, to identify DNA regions in Schizosaccharomyces pombe that fold into G4 structures, we first optimized a quantitative PCR (qPCR) assay using the G4 stabilizer, PhenDC3. We call this method the qPCR stop assay, and used it to screen for G4 structures in genomic DNA. The presence of...
Published in DNA Repair3.71
Erin Walsh1
Estimated H-index: 1
(NIH: National Institutes of Health),
Sarah S. Henrikus2
Estimated H-index: 2
(Illawarra Health & Medical Research Institute)
+ -3 AuthorsPiotr Jonczyk17
Estimated H-index: 17
(PAN: Polish Academy of Sciences)
Abstract pol VICE391 (RumAʹ2B) is a low-fidelity polymerase that promotes considerably higher levels of spontaneous “SOS-induced” mutagenesis than the related E. coli pol V (UmuDʹ2C). The molecular basis for the enhanced mutagenesis was previously unknown. Using single molecule fluorescence microscopy to visualize pol V enzymes, we discovered that the elevated levels of mutagenesis are likely due, in part, to prolonged binding of RumB to genomic DNA leading to its increased levels of DNA synthes...
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