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DNA Repair
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Papers 2725
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#1Fabienne E. Bayer (University of Hohenheim)H-Index: 1
#2Sebastian Deichsel (University of Hohenheim)
Last.Anja C. Nagel (University of Hohenheim)H-Index: 18
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Abstract Genomic integrity is challenged by endo- and exogenous assaults that are combated by highly conserved DNA repair mechanisms. Repair of DNA double-strand breaks (DSBs) is of particular importance, as DSBs inflict chromosome breaks that are the basis of genomic instability. High fidelity recombination repair of DSBs relies on the Rad51 recombinase, aided by several Rad51 paralogs. Despite their significant contribution to DSB repair, the individual roles for Rad51 paralogs are incompletel...
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#2Mengyuan LiH-Index: 4
Last.Xiaosheng WangH-Index: 12
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Abstract Many studies have shown that TP53 mutations play a negative role in antitumor immunity. However, a few studies reported that TP53 mutations could promote antitumor immunity. To explain these contradictory findings, we analyzed five cancer cohorts from The Cancer Genome Atlas (TCGA) project. We found that TP53-mutated cancers had significantly higher levels of antitumor immune signatures than TP53-wildtype cancers in breast invasive carcinoma (BRCA) and lung adenocarcinoma (LUAD). In con...
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#1Sofiane Mokrani (Université Paris-Saclay)
Last.François D. BoussinH-Index: 24
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Abstract High fidelity of genetic transmission in neural stem and progenitor cells (NSPCs) has been long time considered to be crucial for brain development and homeostasis. However, recent studies have identified recurrent DSB clusters in dividing NSPCs, which may underlie the diversity of neuronal cell types. This raised the interest in understanding how NSPCs sense and repair DSBs and how this mechanism could be altered by environmental genotoxic stress caused by pollutants or ionizing radiat...
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#1Hui-Lan Chang (NTU: National Taiwan University)
#2Kang-Yi Su (NTU: National Taiwan University)H-Index: 15
Last.Woei-horng Fang (NTU: National Taiwan University)H-Index: 12
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ABSTRACT Small nucleotide Insertion/deletion (indel) errors are one of the common replication errors in DNA synthesis. The most frequent occurrence of indel error was thought to be due to repeated sequences being prone to slippage during DNA replication. Proofreading and DNA mismatch repair are important factors in indel error correction to maintain the high fidelity of genetic information transactions. We employed a MALDI-TOF mass spectrometry (MS) analysis to measure the efficiency of Klenow p...
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#1Margarita Karapetian (UGA: University of Georgia)H-Index: 1
#2Sophiko Tsikarishvili (UGA: University of Georgia)
Last.Giorgi Zaalishvili (UGA: University of Georgia)
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Abstract Topoisomerase poisons are known to stabilize covalent enzyme-DNA intermediates forming covalent cleavage complexes, which are highly cytotoxic especially for dividing cells and thus, make topoisomerases targets for cancer therapy. Topoisomerases have been extensively studied in mammalian model systems, whereas in other vertebrate models including zebrafish, they still remain less characterized. Here we show similarities in the genotoxic effects of zebrafish and mammalian systems towards...
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#1Jun-ichi Akagi (Gakushuin University)H-Index: 7
#2Keiji Hashimoto (SUNY: State University of New York System)H-Index: 6
Last.Fumio Hanaoka (Gakushuin University)H-Index: 77
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Abstract The (6-4) pyrimidine–pyrimidone photoproduct [(6-4)PP] is a major DNA lesion induced by ultraviolet radiation. (6-4)PP induces complex mutations opposite its downstream bases, in addition to opposite 3′ or 5′ base, as has been observed through a site-specific translesion DNA synthesis (TLS) assay. The mechanism by which these mutations occur is not well understood. To elucidate the mechanisms underlying mutagenesis induced by (6-4)PP, we performed an intracellular TLS assay using a repl...
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#2Upasna ThaparH-Index: 2
Last.Bruce DempleH-Index: 66
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Abstract Free radical attack on C1′ of deoxyribose forms the oxidized abasic (AP) site 2-deoxyribonolactone (dL). In vitro, dL traps the major base excision DNA repair enzyme DNA polymerase beta (Polβ) in covalent DNA-protein crosslinks (DPC) via the enzyme’s N-terminal lyase activity acting on 5′-deoxyribose-5-phosphate residues. We previously demonstrated formation of Polβ-DPC in cells challenged with oxidants generating significant levels of dL. Proteasome inhibition under 1,10-copper-ortho-p...
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Abstract Cellular processes, such as DNA replication, recombination and transcription, require DNA strands separation and single-stranded DNA is formation. The single-stranded DNA is promptly wrapped by human single-stranded DNA binding proteins, replication protein A (RPA) complex. RPA binding not only prevent nuclease degradation and annealing, but it also coordinates cell-cycle checkpoint activation and DNA repair. However, RPA binding offers little protection against the chemical modificatio...
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#2Daniel GebhardH-Index: 5
Last.Jörg BergemannH-Index: 9
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Abstract The DNA of human cells suffers about 1.000 to 100.000 oxidative lesions per day. One of the most common defects in this category is represented by 7,8-dihydro-8-oxoguanine. There are numerous exogenous effects on DNA that induce the intracellular generation of 7, 8-dihydro-8-oxoguanine. Therefore, a quantitatively sufficient repair of all occurring oxidative damaged guanine bases is often only partially feasible, especially in advanced age. Inadequate removal of these damages can subseq...
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#1Yuqin CaiH-Index: 16
#2Nicholas E. Geacintov (NYU: New York University)H-Index: 54
Last.Suse BroydeH-Index: 37
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Abstract The packaging of DNA in nucleosomes presents a barrier for biological transactions including replication, transcription and repair. However, despite years of research, how the DNA is freed from the histone proteins and thereby allows the molecular machines to access the DNA remains poorly understood. We are interested in global genomic nucleotide excision repair (GG-NER). It is established that the histones are obstacles to this process, and DNA lesions are repaired less efficiently in ...
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Top fields of study
DNA repair
Molecular biology
Genetics
DNA
Biology